SCHEMBL537455

SCHEMBL537455

COc1nc2c(c(OC)n1)N=C[N]2

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1025894 0.79 CCNA2 (0.37)
SCHEMBL23249524 0.65 CYP1A2 (0.33) CYP1A2
SCHEMBL7809922 0.62 CDK1 (0.31)
SCHEMBL4271009 0.62 CYP1A2 (0.40) CYP1A2
SCHEMBL8886043 0.61 CDK1 (0.42)
SCHEMBL5765829 0.60 CYP1A2 (0.39) CYP1A2
SCHEMBL2725593 0.60 TSHR (0.42) CYP1A2
SCHEMBL24344234 0.60 CYP1A2 (0.39) CYP1A2
SCHEMBL33145 0.59 ALDH1A1 (0.43) CYP1A2
SCHEMBL11817267 0.58 MAPT (0.33) CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 198 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230340008-A1 BRIDGED NUCLEOSIDE AND NUCLEOTIDE USING SAME JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES (JP) 2023-10-26 US claimed
WO-2023167094-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME 国立大学法人大阪大学 2023-09-07 WO claimed
US-20230124641-A1 CROSS-LINKED NUCLEOSIDE AND NUCLEOTIDE USING SAME JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES (JP) 2023-04-20 US claimed
EP-4108262-A1 CROSS-LINKED NUCLEOSIDE AND NUCLEOTIDE USING SAME OSAKA UNIVERSITY (JP) 2022-12-28 EP claimed
EP-4108670-A1 BRIDGED NUCLEOSIDE AND NUCLEOTIDE USING SAME OSAKA UNIVERSITY (JP) 2022-12-28 EP claimed
CN-115135658-A Bridged nucleoside and nucleotide using the same 国立大学法人大阪大学 2022-09-30 CN claimed
US-20220127300-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME OSAKA UNIVERSITY (JP) 2022-04-28 US claimed
WO-2022004388-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME 国立大学法人大阪大学 2022-01-06 WO claimed
EP-3925965-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME Osaka University (JP) 2021-12-22 EP claimed
EP-3919501-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME Osaka University (JP) 2021-12-08 EP claimed
US-20050176941-A1 Nucleoside analogues whose sugar moieties are bound in s-form and oligonucleotide derivatives comprising nucleotide analogues thereof TAKESHI IMANISHI (JP) 2005-08-11 US claimed
EP-1152009-B1 NOVEL NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGUES SANKYO CO (JP) 2005-01-26 EP claimed
EP-1486504-A1 NUCLEOSIDE ANALOGUES WHOSE SUGAR MOIETIES ARE BOUND IN S-FORM AND OLIGONUCLEOTIDE DERIVATIVES COMPRISING NUCLEOTIDE ANALOGUES THEREOF Imanishi, Takeshi (JP) 2004-12-15 EP claimed
EP-1481983-A1 NUCLEOSIDE ANALOGUES AND OLIGONUCLEOTIDE DERIVATIVE COMPRISING NUCLEOTIDE ANALOGUE THEREOF Imanishi, Takeshi (JP) 2004-12-01 EP claimed
EP-1201678-B1 NOVEL BICYCLONUCLEOSIDE ANALOGUES SANKYO CO (JP) 2004-09-22 EP claimed
US-20040143114-A1 Novel bicyclonucleoside analogues SANKYO COMPANY, LIMITED (JP) 2004-07-22 US claimed
US-20030207841-A1 Novel nucleoside and oligonucleotide analogues SANKYO COMPANY LIMITED (JP) 2003-11-06 US claimed
US-20020147332-A1 Novel nucleoside and oligonucleotide analogues SANKYO COMPANY, LIMITED (JP) 2002-10-10 US claimed
EP-1201678-A1 NOVEL BICYCLONUCLEOSIDE ANALOGUES Sankyo Company, Limited (JP) 2002-05-02 EP claimed
EP-1152009-A1 NOVEL NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGUES Sankyo Company, Limited (JP) 2001-11-07 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020147332-A1 Novel nucleoside and oligonucleotide analogues RNGTT, NSUN2, MTAP CYP1A2 4335/4885
US-20050176941-A1 Nucleoside analogues whose sugar moieties are bound in s-form and oligonucleotide derivatives comprising nucleotide analogues thereof RNGTT, NSUN2, SNRPE CYP1A2 3885/4885
US-20230340008-A1 BRIDGED NUCLEOSIDE AND NUCLEOTIDE USING SAME SLC29A1, SLC29A2, PNP CYP1A2 3346/4885
US-20030207841-A1 Novel nucleoside and oligonucleotide analogues RNGTT, NSUN2, MTAP CYP1A2 4335/4885
US-20230124641-A1 CROSS-LINKED NUCLEOSIDE AND NUCLEOTIDE USING SAME RNGTT, NUDT1, SLC29A2 CYP1A2 2587/4885
US-20040143114-A1 Novel bicyclonucleoside analogues PURB, DUT, NSUN2 CYP1A2 4287/4885
US-20220127300-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME NT5C3B, DUT, RNGTT CYP1A2 2197/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.