Sugi Predict

Sugi Predict / Compounds / SCHEMBL5375243

SCHEMBL5375243

SCHEMBL5375243

Clc1ccccc1-c1nn2c(Cl)ccnc2c1I

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 1/20 0.37
▸ ALDH1A1 P00352 5/20 0.36
▸ SMN1; SMN2 Q16637 4/20 0.36
▸ NPC1 O15118 2/20 0.36
▸ RAB9A P51151 2/20 0.36
▸ LMNA P02545 1/20 0.36
▸ CDK2 P24941 2/20 0.35
▸ CCNE2 O96020 1/20 0.35
▸ CCNE1 P24864 1/20 0.35
▸ XDH P47989 1/20 0.33
▸ EGLN2 Q96KS0 1/20 0.33
▸ PDE2A O00408 1/20 0.33
▸ HPGD P15428 3/20 0.33
▸ KDM4E B2RXH2 2/20 0.33
▸ ALOX15 P16050 2/20 0.33
▸ MAPK1 P28482 2/20 0.33
▸ MAPT P10636 1/20 0.33
▸ DCTPP1 Q9H773 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14577428 0.79 GPR119 (0.35) DPP4ALDH1A1SMN1; SMN2PDE2AHPGD
SCHEMBL5380218 0.78 NPC1 (0.47) ALDH1A1SMN1; SMN2NPC1RAB9ACDK2
SCHEMBL5386879 0.76 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2NPC1RAB9ALMNA
SCHEMBL4834205 0.75 XDH (0.43) ALDH1A1CDK2CCNE2CCNE1XDH
SCHEMBL4840877 0.71 KMT2A (0.37) ALDH1A1SMN1; SMN2NPC1RAB9ALMNA
SCHEMBL30871372 0.71 L3MBTL1 (0.30) LMNAL3MBTL1
SCHEMBL4843180 0.69 XDH (0.47) XDHKDM4ETP53HSD17B10
SCHEMBL5564478 0.67 AURKA (0.47) ALDH1A1SMN1; SMN2NPC1RAB9ALMNA
SCHEMBL5385950 0.67 MAPT (0.46) DPP4ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL5380215 0.66 NPC1 (0.62) ALDH1A1SMN1; SMN2NPC1RAB9ACDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7176210-B2 Cannabinoid receptor ligands and uses thereof PFIZER INC. (US) 2007-02-13 — — US disclosed
US-7176210-B2 Cannabinoid receptor ligands and uses thereof PFIZER INC. (US) 2007-02-13 — — US disclosed
US-7176210-B2 Cannabinoid receptor ligands and uses thereof PFIZER INC. (US) 2007-02-13 — — US disclosed
EP-1594872-A1 CANNABINOID RECEPTOR LIGANDS AND USES THEREOF Pfizer Products Inc. (US) 2005-11-16 — — EP disclosed
WO-2005103052-A1 PYRAZOLO [1,5-A] PYRIMIDIN-7-ONE COMPOUNDS AND USES THEREOF PFIZER PRODUCTS INC. (US) 2005-11-03 — — WO disclosed
WO-2004069838-A1 CANNABINOID RECEPTOR LIGANDS AND USES THEREOF PFIZER PRODUCTS INC. (US) 2004-08-19 — — WO disclosed
US-20040157838-A1 Cannabinoid receptor ligands and uses thereof PFIZER INC 2004-08-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040157838-A1 Cannabinoid receptor ligands and uses thereof CNR1, CNR2, GPR18 DPP4 3718/4885ALDH1A1 1683/4885SMN1; SMN2 3678/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.