Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.40 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5564715 | 0.76 | AURKA (0.45) | AURKACCNA2CDK2MAPTSMN1; SMN2 | |
| SCHEMBL14844903 | 0.71 | AXL (0.42) | AURKACCNA2CDK2MAPTSMN1; SMN2 | |
| SCHEMBL14557189 | 0.70 | AURKA (0.43) | AURKAMAPTSMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL3780252 | 0.69 | RAB9A (0.59) | MAPTSMN1; SMN2MAPK1ALDH1A1NPC1 | |
| SCHEMBL18190043 | 0.69 | AURKA (0.39) | AURKACCNA2CDK2MAPTSMN1; SMN2 | |
| SCHEMBL18190104 | 0.67 | AURKA (0.43) | AURKAMAPTSMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL5375243 | 0.67 | DPP4 (0.37) | CCNA2CDK2MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL5564110 | 0.66 | NPC1 (0.60) | AURKAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL18004666 | 0.65 | MAPT (0.51) | AURKACCNA2CDK2MAPTSMN1; SMN2 | |
| SCHEMBL556037 | 0.63 | KMT2A (0.52) | AURKAMAPTSMN1; SMN2MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1504004-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES | SMITHKLINE BEECHAM CORP (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20050203106-A1 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203106-A1 | Therapeutic compounds | ABCB1, PCSK9, ABCB11 | AURKA 1984/4885CCNA2 2829/4885CDK2 1439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.