Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 10/20 | 0.50 |
| ▸ | TLR4 | O00206 | 4/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436284 | 0.86 | ADRB2 (0.55) | ADRB2TLR4DRD2ADRB1ADRB3 | |
| SCHEMBL4608624 | 0.80 | ADRB2 (0.47) | ADRB2TLR4DRD2ADRB1ADRB3 | |
| SCHEMBL6552584 | 0.79 | ADRB3 (0.43) | ADRB2ADRB1ADRB3MAPTKDM4E | |
| SCHEMBL5375723 | 0.78 | ADRB2 (0.62) | ADRB2TLR4DRD2ADRB1ADRB3 | |
| SCHEMBL7143716 | 0.78 | HTR6 (0.43) | DRD2MAPTKDM4EHTR6KMT2A | |
| SCHEMBL13204418 | 0.76 | ADRB2 (0.65) | ADRB2TLR4DRD2ADRB1ADRB3 | |
| SCHEMBL11080474 | 0.75 | HTR1A (0.43) | MAPTKDM4EHTR1AADRA1DADRA1A | |
| SCHEMBL789339 | 0.75 | ADRB2 (0.63) | ADRB2TLR4DRD2ADRB1ADRB3 | |
| SCHEMBL4606845 | 0.73 | ADRB2 (0.42) | ADRB2TLR4DRD2ADRB1ADRB3 | |
| SCHEMBL4555826 | 0.73 | ADRB2 (0.68) | ADRB2TLR4DRD2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169935-B2 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. (US) | 2007-01-30 | — | — | US | claimed |
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | SCALONE MICHELANGELO (CH) | 2004-07-01 | — | — | US | claimed |
| EP-1355880-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-29 | — | — | EP | claimed |
| WO-2002059089-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | claimed |
| EP-1355880-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002059089-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | CYP3A4, CYP8B1, CYP51A1 | ADRB2 2361/4885TLR4 3096/4885DRD2 4101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.