Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5380681 | 0.81 | POLB (0.46) | HTR6DRD2MTNR1BLMNAHPGD | |
| SCHEMBL5375729 | 0.78 | ADRB2 (0.50) | HTR6DRD2LMNAKMT2ABCHE | |
| SCHEMBL11080474 | 0.72 | HTR1A (0.43) | LMNAHPGDPOLBKMT2AMAPT | |
| SCHEMBL6552584 | 0.66 | ADRB3 (0.43) | MAPTKDM4ECYP3A4TSHRCYP2C19 | |
| SCHEMBL5376311 | 0.65 | MTNR1B (0.45) | HTR6DRD2MTNR1BLMNAKMT2A | |
| SCHEMBL4436284 | 0.64 | ADRB2 (0.55) | HTR6DRD2LMNAKMT2ABCHE | |
| SCHEMBL8150115 | 0.62 | LMNA (0.53) | LMNAPOLBKMT2AMEN1BCHE | |
| SCHEMBL6554335 | 0.62 | L3MBTL1 (0.46) | POLBMAPTALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL5378582 | 0.61 | ALDH1A1 (0.43) | HTR6MTNR1BLMNABCHEKDM4E | |
| SCHEMBL16550062 | 0.61 | MAPT (0.44) | HTR6DRD2LMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355880-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-29 | — | — | EP | claimed |
| WO-2002059089-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | claimed |
| EP-1355880-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002059089-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | disclosed |