SCHEMBL5376527

SCHEMBL5376527

NCC=C1C2CC3CC(C2)CC1C3

nearest known ligand 0.41

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9638829 0.75 TSHR (0.46) TSHR
SCHEMBL9638454 0.75 TSHR (0.41) TSHR
SCHEMBL7627471 0.70 TSHR (0.46) TSHR
SCHEMBL339727 0.67 TSHR (0.39) TSHR
SCHEMBL6557963 0.67 TSHR (0.48) TSHR
Adamantane SCHEMBL2284749 0.64 ALDH1A1 (0.60)
SCHEMBL4791985 0.62 TSHR (0.43) TSHR
Adamantane SCHEMBL28705266 0.61 GRIN2D (0.45) TSHR
SCHEMBL1072862 0.60 TSHR (0.41) TSHR
SCHEMBL2488748 0.60 TSHR (0.41) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7192606-B2 Drugs for treating viral infections VASSIL STEFANOV GEORGIEV (US) 2007-03-20 US disclosed
US-7192606-B2 Drugs for treating viral infections VASSIL STEFANOV GEORGIEV (US) 2007-03-20 US disclosed
US-7192606-B2 Drugs for treating viral infections VASSIL STEFANOV GEORGIEV (US) 2007-03-20 US disclosed
US-20050192358-A1 Drugs for treating viral infections GEORGIEV VASSIL S (US) 2005-09-01 US disclosed
US-6596771-B2 Imidodisulfamide derivatives SCHERING CORPORATION 2003-07-22 US disclosed
WO-2003004461-A1 DRUGS FOR TREATING VIRAL INFECTIONS SCHERING CORPORATION (US) 2003-01-16 WO disclosed
US-20020193443-A1 Drugs for treating viral infections SCHERING CORPORATION 2002-12-19 US disclosed
US-20020132851-A1 DRUGS FOR TREATING VIRAL INFECTIONS GEORGIEV VASSIL STEFANOV (US) 2002-09-19 US disclosed
US-6433016-B1 CARBOCYCLIC IMIDODISULFAMIDE DERIVATIVE VIRICIDES FOR ORTHOPOXVIRUSES GEORGIEV VASSIL STEFANOV (US) 2002-08-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050192358-A1 Drugs for treating viral infections ITPA, MAVS, PPIP5K2 TSHR 3964/4885
US-20020132851-A1 DRUGS FOR TREATING VIRAL INFECTIONS EIF2AK2, MAVS, SORD TSHR 4261/4885
US-20020193443-A1 Drugs for treating viral infections EIF2AK2, MAVS, DDX5 TSHR 3351/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.