Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29354503 | 0.92 | ALDH1A1 (0.43) | MAPK1HPSEALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL528860 | 0.92 | ALDH1A1 (0.43) | MAPK1HPSEALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL1395479 | 0.88 | POLB (0.49) | MAPK1POLBATMSIRT2ALDH1A1 | |
| SCHEMBL3127639 | 0.87 | ALDH1A1 (0.47) | MAPK1HPSEALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL22262037 | 0.85 | ALDH1A1 (0.43) | MAPK1HPSEALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL29357885 | 0.85 | ALDH1A1 (0.43) | MAPK1HPSEALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL2421131 | 0.83 | ALDH1A1 (0.41) | MAPK1HPSEALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL16765694 | 0.83 | SIRT2 (0.45) | MAPK1POLBATMSIRT2ALDH1A1 | |
| SCHEMBL29361802 | 0.83 | SIRT2 (0.45) | MAPK1POLBATMSIRT2ALDH1A1 | |
| SCHEMBL44480 | 0.83 | SIRT2 (0.45) | MAPK1POLBATMSIRT2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288661-B2 | Process for the synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2007-10-30 | — | — | US | claimed |
| US-20070123581-A1 | Process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2007-05-31 | — | — | US | claimed |
| US-20070093663-A1 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof. | LES LABORATOIRES SERVIER (FR) | 2007-04-26 | — | — | US | claimed |
| US-7288661-B2 | Process for the synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2007-10-30 | — | — | US | disclosed |
| US-7279583-B2 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof | LES LABORATOIRES SERVIER (FR) | 2007-10-09 | — | — | US | disclosed |
| US-20070123581-A1 | Process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | LES LABORATOIRES SERVIER (FR) | 2007-05-31 | — | — | US | disclosed |
| US-20070093663-A1 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof. | LES LABORATOIRES SERVIER (FR) | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093663-A1 | Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof. | QDPR, REN, ACE | MAPK1 1744/4885POLB 2909/4885ATM 4395/4885 |
| US-20070123581-A1 | Process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril | CYP2S1, TPH1, AGTR1 | MAPK1 753/4885POLB 3241/4885ATM 3947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.