Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29788177 | 0.94 | LMNA (0.39) | LMNADPP4PDCD1CD274ALDH1A1 | |
| SCHEMBL30462313 | 0.88 | DPP4 (0.44) | LMNADPP4PDCD1CD274ALDH1A1 | |
| SCHEMBL5391697 | 0.84 | GSTP1 (0.44) | ALDH1A1HSD17B10MMP3TNFPTGS2 | |
| SCHEMBL7743971 | 0.78 | RXRA (0.48) | LMNAALDH1A1MAPK1TDP1 | |
| SCHEMBL1343377 | 0.77 | DPP4 (0.56) | LMNADPP4PDCD1CD274ALDH1A1 | |
| SCHEMBL4193873 | 0.77 | HPRT1 (0.49) | LMNAALDH1A1HPGDMAPK1MMP3 | |
| SCHEMBL13385994 | 0.76 | LMNA (0.44) | LMNADPP4PDCD1CD274ALDH1A1 | |
| SCHEMBL22234041 | 0.75 | DPP4 (0.44) | LMNADPP4PDCD1CD274ALDH1A1 | |
| SCHEMBL16056461 | 0.74 | FOLH1 (0.62) | DPP4PDCD1CD274ALDH1A1HPGD | |
| SCHEMBL9570522 | 0.74 | CD274 (0.65) | DPP4PDCD1CD274ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285682-B2 | Terphenyl guanidines as β-secretase inhibitors | WYETH (US) | 2007-10-23 | — | — | US | disclosed |
| WO-2006088705-A1 | TERPHENYL GUANIDINES AS [BETA SYMBOL] -SECRETASE INHIBITORS | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |
| US-20060183943-A1 | Terphenyl guanidines as beta-secretase inhibitors | WYETH (US) | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183943-A1 | Terphenyl guanidines as beta-secretase inhibitors | BACE1, BACE2, APP | LMNA 1130/4885DPP4 122/4885PDCD1 2601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.