Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | RXRG | P48443 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ATP4A | P20648 | 1/20 | 0.45 |
| ▸ | ATP4B | P51164 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11857664 | 0.85 | MAPK1 (0.45) | RXRARXRBRXRGMAPK1MAPT | |
| SCHEMBL8406800 | 0.82 | MAPK1 (0.47) | MAPK1MAPTTDP1L3MBTL1MEN1 | |
| SCHEMBL6036331 | 0.82 | MAPK1 (0.51) | RXRAMAPK1MAPTTDP1L3MBTL1 | |
| SCHEMBL8874717 | 0.81 | SQOR (0.57) | RXRARXRBRXRGMAPK1MAPT | |
| SCHEMBL201074 | 0.78 | RXRA (0.70) | RXRARXRBRXRGMAPK1MAPT | |
| SCHEMBL5380662 | 0.78 | LMNA (0.42) | MAPK1TDP1ALDH1A1LMNA | |
| SCHEMBL8406051 | 0.76 | SGMS2 (0.54) | MAPK1MAPTTDP1L3MBTL1MEN1 | |
| SCHEMBL11857656 | 0.76 | MAPK1 (0.45) | MAPK1MAPTTDP1L3MBTL1PTGER1 | |
| SCHEMBL3150720 | 0.76 | HTR1A (0.61) | MAPK1MAPTTDP1L3MBTL1MEN1 | |
| SCHEMBL6640539 | 0.76 | MAPT (0.55) | RXRARXRBRXRGMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091736-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1091736-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001382-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |