Sugi Predict

Sugi Predict / Compounds / SCHEMBL1343377

SCHEMBL1343377

SCHEMBL1343377

N#CCc1ccccc1-c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 1/20 0.56
▸ KMT2A Q03164 1/20 0.47
▸ ALDH1A1 P00352 4/20 0.46
▸ HPGD P15428 2/20 0.46
▸ PDCD1 Q15116 1/20 0.44
▸ CD274 Q9NZQ7 1/20 0.44
▸ ATR Q13535 1/20 0.43
▸ KCNA5 P22460 3/20 0.43
▸ KCNH2 Q12809 2/20 0.43
▸ ADRA2C P18825 1/20 0.42
▸ LMNA P02545 1/20 0.42
▸ HTR7 P34969 1/20 0.41
▸ FOLH1 Q04609 1/20 0.41
▸ CYP11B1 P15538 1/20 0.41
▸ CYP11B2 P19099 1/20 0.41
▸ HSD17B10 Q99714 2/20 0.39
▸ BCL2L1 Q07817 1/20 0.39
▸ CYP2A6 P11509 1/20 0.39
▸ MAPK1 P28482 1/20 0.39
▸ PTGER1 P34995 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29950055 0.86 DPP4 (0.42) DPP4KMT2AALDH1A1HPGDPDCD1
SCHEMBL29019013 0.85 TNF (0.47) DPP4KMT2AALDH1A1HPGDATR
SCHEMBL29842617 0.85 TNF (0.47) DPP4KMT2AALDH1A1HPGDATR
SCHEMBL13385994 0.84 LMNA (0.44) DPP4KMT2AALDH1A1HPGDPDCD1
Carbazole SCHEMBL28602507 0.84 EGFR (0.46) DPP4KMT2AALDH1A1HPGDPDCD1
SCHEMBL8046052 0.84 PTGS2 (0.41) DPP4ALDH1A1HPGDHTR7
SCHEMBL4666102 0.84 ESR2 (0.56) DPP4KMT2AALDH1A1HPGDBCL2L1
SCHEMBL22234041 0.84 DPP4 (0.44) DPP4KMT2AALDH1A1HPGDPDCD1
SCHEMBL28812241 0.84 KCNA5 (0.51) DPP4ALDH1A1HPGDATRKCNA5
SCHEMBL30462313 0.84 DPP4 (0.44) DPP4KMT2AALDH1A1HPGDPDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115109054-A Preparation method and application of color-changing material with multiple stimulus responses 湖州学院 2022-09-27 — — CN claimed
CN-117434165-A Method for detecting felbinac related substances 河北以岭医药研究院有限公司 2024-01-23 — — CN disclosed
US-11572374-B2 N-cyano-7-azanorbornane derivatives and uses thereof AMGEN INC. (US) 2023-02-07 — — US disclosed
CN-112961098-B Organic fluorescent material containing pyrene unit and having aggregation induced luminescence, and preparation method and application thereof 广东工业大学 2023-01-20 — — CN disclosed
US-20220363694-A1 N-CYANO-7-AZANORBORNANE DERIVATIVES AND USES THEREOF AMGEN INC. (US) 2022-11-17 — — US disclosed
CN-115109054-A Preparation method and application of color-changing material with multiple stimulus responses 湖州学院 2022-09-27 — — CN disclosed
US-10799510-B2 Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists GENFIT (FR) 2020-10-13 — — US disclosed
US-20170296548-A1 DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS GENFIT (FR) 2017-10-19 — — US disclosed
US-9586963-B2 Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists GENFIT (FR) 2017-03-07 — — US disclosed
EP-2583958-B1 Ligands for metals and improved metal-catalyzed processes based thereon MASSACHUSETTS INST TECHNOLOGY (US) 2016-08-10 — — EP disclosed
EP-0796852-A1 Process for preparation of 5-substituted tetrazoles Toyo Kasei Kogyo Company Limited (JP) 1997-09-24 — — EP disclosed
US-5654315-A ENZYME INHIBITORS AS ANTICHOLESTEROL AGENTS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1997-08-05 — — US disclosed
EP-0626960-A1 QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS ZENECA LIMITED (GB) 1994-12-07 — — EP disclosed
WO-1993013096-A1 QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-07-08 — — WO disclosed
EP-0015776-B1 1,1'-BIPHENYL-2-YL ALKYLAMINE DERIVATIVES, THEIR PRODUCTION AND CARDIOVASCULAR PREPARATIONS CONTAINING SAME ELI LILLY AND COMPANY (US) 1982-06-30 — — EP disclosed
US-4277471-A 1,1-Biphenyl-2-yl alkylamines, formulations and antiarrhythmic treatment ELI LILLY AND COMPANY (US) 1981-07-07 — — US disclosed
EP-0015776-A1 1,1'-Biphenyl-2-yl alkylamine derivatives, their production and cardiovascular preparations containing same ELI LILLY AND COMPANY (US) 1980-09-17 — — EP disclosed
US-3984559-A Compositions comprising tetramic acid analogs of pulvinic acid and methods of combating arthritis SMITHKLINE CORPORATION (US) 1976-10-05 — — US disclosed
US-3947580-A Anti-arthritic compositions comprising N-heterocyclic pulvinic acid amides and methods of producing anti-arthritic activity SMITHKLINE CORPORATION (US) 1976-03-30 — — US disclosed
US-3931207-A ANTIARTHRITIC SMITHKLINE CORPORATION (US) 1976-01-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10799510-B2 Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists NR1D1, NR1D2, PER2 DPP4 531/4885KMT2A 1958/4885ALDH1A1 2864/4885
US-11572374-B2 N-cyano-7-azanorbornane derivatives and uses thereof CYP3A7, CYP51A1, NT5C3B DPP4 3065/4885KMT2A 2971/4885ALDH1A1 793/4885
US-20170296548-A1 DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS NR1D1, NR1D2, PER2 DPP4 531/4885KMT2A 1958/4885ALDH1A1 2864/4885
US-20220363694-A1 N-CYANO-7-AZANORBORNANE DERIVATIVES AND USES THEREOF CYP3A7, CYP51A1, NT5C3B DPP4 3065/4885KMT2A 2971/4885ALDH1A1 793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.