Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143716 | 0.81 | HTR6 (0.43) | POLBHTR6TSHRALDH1A1LMNA | |
| SCHEMBL5375723 | 0.78 | ADRB2 (0.62) | POLBHTR6TSHRALDH1A1LMNA | |
| SCHEMBL11080480 | 0.72 | POLB (0.50) | POLBTSHRALDH1A1LMNAGAA | |
| SCHEMBL16550062 | 0.72 | MAPT (0.44) | HTR6TSHRALDH1A1LMNAGAA | |
| SCHEMBL17946178 | 0.72 | ADRB2 (0.58) | HTR6LMNAGAAKMT2AMAPT | |
| SCHEMBL13916263 | 0.71 | POLB (0.49) | POLBTSHRALDH1A1LMNAGAA | |
| Methyl Alcohol SCHEMBL11168835 | 0.71 | ALDH1A1 (0.53) | POLBTSHRALDH1A1LMNAGAA | |
| SCHEMBL11548958 | 0.70 | POLB (0.57) | POLBTSHRALDH1A1LMNAGAA | |
| SCHEMBL4555826 | 0.70 | ADRB2 (0.68) | HTR6LMNAGAAKMT2AMAPT | |
| SCHEMBL8277013 | 0.70 | ADRB2 (0.68) | HTR6LMNAGAAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169935-B2 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. (US) | 2007-01-30 | — | — | US | claimed |
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | SCALONE MICHELANGELO (CH) | 2004-07-01 | — | — | US | claimed |
| EP-1355880-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-29 | — | — | EP | claimed |
| WO-2002059089-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | claimed |
| US-20020099223-A1 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. | 2002-07-25 | — | — | US | claimed |
| US-7169935-B2 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-6777559-B2 | CYCLOCARBONYLATING ACETIC ACID (OR BENZOIC ACID)-1-(1-BENZENESULFONYL-1H-INDOL-2-YL)-ALLYL ESTER TO OBTAIN 9-BENZENESULFONYL-9H-CARBAZOL-4-YL ESTER; SAPONIFYING | HOFFMANN-LA ROCHE INC. | 2004-08-17 | — | — | US | disclosed |
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | SCALONE MICHELANGELO (CH) | 2004-07-01 | — | — | US | disclosed |
| EP-1355880-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002059089-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | disclosed |
| US-20020099223-A1 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. | 2002-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | CYP3A4, CYP8B1, CYP51A1 | POLB 446/4885HTR6 3297/4885TSHR 4611/4885 |
| US-20020099223-A1 | Process for preparing heterocyclic indene analogs | CYP3A4, CYP8B1, CYP51A1 | POLB 446/4885HTR6 3297/4885TSHR 4611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.