Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.35 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.35 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5379943 | 0.74 | HRH4 (0.44) | HRH4HRH3ADORA2AKCNH2BCHE | |
| SCHEMBL13804704 | 0.68 | PIM1 (0.43) | BCHEPIM1TRPC3TRPC4TRPC5 | |
| SCHEMBL6034415 | 0.67 | BCHE (0.72) | KCNH2BCHETRPC3TRPC4TRPC5 | |
| SCHEMBL5394585 | 0.64 | CHEK1 (0.50) | BCHEPIM1TRPC3TRPC4TRPC5 | |
| SCHEMBL5382890 | 0.64 | BCHE (0.48) | HRH3BCHEPIM1TRPC3TRPC4 | |
| Trifluoroacetic Acid SCHEMBL2953478 | 0.63 | HDAC11 (0.43) | HRH4HRH3ALDH1A1 | |
| SCHEMBL4640893 | 0.63 | BCHE (0.70) | KCNH2BCHETRPC3TRPC4TRPC5 | |
| SCHEMBL18934416 | 0.63 | KDM4E (0.70) | BCHETRPC3TRPC4TRPC5ALDH1A1 | |
| SCHEMBL17513341 | 0.62 | PIM1 (0.42) | HRH3KCNH2BCHEPIM1TRPC3 | |
| SCHEMBL6439777 | 0.62 | BCHE (0.68) | KCNH2BCHETRPC3TRPC4TRPC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070213362-A1 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | REPLIDYNE, INC. (US) | 2007-09-13 | — | — | US | disclosed |
| US-7220757-B2 | Compositions and methods for topical administration of 2-NH-heteroarylimidazoles | REPLIDYNE, INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-20060128735-A1 | Substituted thiophenes with antibacterial activity | REPLIDYNE, INC. (US) | 2006-06-15 | — | — | US | disclosed |
| US-7030137-B2 | Substituted thiophenes with antibacterial activity | REPLIDYNE, INC. (US) | 2006-04-18 | — | — | US | disclosed |
| US-20060014748-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | BERGE JOHN | 2006-01-19 | — | — | US | disclosed |
| US-6943175-B2 | 2-NH-heteroarylimidazoles with antibacterial activity | REPLIDYNE, INC. (US) | 2005-09-13 | — | — | US | disclosed |
| US-20050009833-A1 | Substituted thiophenes with antibacterial activity | REPLIDYNE, INC. | 2005-01-13 | — | — | US | disclosed |
| US-20040147548-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | REPLIDYNE, INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147548-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | NSUN3, TRMT1, NOP2 | HRH4 2734/4885HRH3 2555/4885ADORA2A 3493/4885 |
| US-20050009833-A1 | Substituted thiophenes with antibacterial activity | TST, MTR, NSUN3 | HRH4 1977/4885HRH3 2173/4885ADORA2A 1890/4885 |
| US-20060128735-A1 | Substituted thiophenes with antibacterial activity | TST, MTR, NSUN3 | HRH4 1977/4885HRH3 2173/4885ADORA2A 1890/4885 |
| US-20070213362-A1 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | MET, ASNS, MRPS22 | HRH4 1366/4885HRH3 792/4885ADORA2A 2626/4885 |
| US-20060014748-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | TRMT1, NSUN3, NOP2 | HRH4 2818/4885HRH3 2683/4885ADORA2A 3498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.