Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4163673 | 0.88 | ACHE (0.42) | ALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL5549018 | 0.85 | NCF1 (0.39) | NCF1ALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL5547464 | 0.83 | SLC6A7 (0.34) | ALDH1A1CYP1A2CYP2C19GRM2HTR1A | |
| SCHEMBL4885947 | 0.78 | HTR1A (0.38) | ALDH1A1MAPTTMEM97SIGMAR1HTR1A | |
| SCHEMBL4178891 | 0.74 | CKS1B (0.43) | ALDH1A1MAPT | |
| SCHEMBL4889066 | 0.72 | HTR7 (0.44) | MAPTMEN1KMT2AHTR7HTR1A | |
| SCHEMBL4887206 | 0.72 | BACE1 (0.51) | MAPTMEN1KMT2A | |
| SCHEMBL4878710 | 0.71 | ACHE (0.42) | ALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL5549046 | 0.69 | KDM4E (0.35) | ALDH1A1MAPTSMN1; SMN2KMT2AHTR7 | |
| SCHEMBL4889339 | 0.68 | SLC6A7 (0.34) | ALDH1A1MAPTGRM2HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789045-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006023400-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-02 | — | — | WO | disclosed |