Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 5/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.32 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547464 | 0.85 | SLC6A7 (0.34) | SLC6A7CXCR3GRM2ALDH1A1DRD4 | |
| SCHEMBL4878710 | 0.78 | ACHE (0.42) | ALDH1A1MAPT | |
| SCHEMBL6971671 | 0.73 | HTR2A (0.45) | SLC6A7ALDH1A1HTR1ASLC6A4MAPT | |
| SCHEMBL5549046 | 0.72 | KDM4E (0.35) | SLC6A7GRM2ALDH1A1DRD4HTR1A | |
| SCHEMBL4009517 | 0.72 | POLB (0.43) | SLC6A7ALDH1A1HTR1ASLC6A4MAPT | |
| SCHEMBL4558300 | 0.71 | SLC6A9 (0.44) | SLC6A7ALDH1A1DRD4HTR6HTR1A | |
| SCHEMBL23037387 | 0.71 | PBRM1 (0.41) | SLC6A7BRD4ALDH1A1MAPT | |
| SCHEMBL2327343 | 0.70 | RBP4 (0.37) | SLC6A7ALDH1A1NPC1 | |
| SCHEMBL4887137 | 0.70 | HTR1A (0.38) | BRD4ALDH1A1DRD4HTR6HTR1A | |
| SCHEMBL2760636 | 0.69 | DRD2 (0.51) | ALDH1A1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045537-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-02-21 | — | — | US | disclosed |
| EP-1789045-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006023400-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045537-A1 | Chemical Compounds | CCR5, CXCR4, CXCR3 | SLC6A7 1632/4885BRD4 427/4885CREBBP 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.