Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5394145 | 1.00 | MAPT (0.34) | MAPTRAB9AL3MBTL1ALDH1A1CHRNB2 | |
| SCHEMBL14408908 | 1.00 | MAPT (0.34) | MAPTRAB9AL3MBTL1ALDH1A1CHRNB2 | |
| SCHEMBL14408909 | 0.86 | L3MBTL1 (0.36) | MAPTRAB9AL3MBTL1ALDH1A1CHRNB2 | |
| SCHEMBL14408910 | 0.86 | ALDH1A1 (0.33) | MAPTRAB9AL3MBTL1ALDH1A1CHRNB2 | |
| SCHEMBL7657443 | 0.84 | CHRNB2 (0.38) | MAPTALDH1A1CHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL7657366 | 0.81 | CHRNB2 (0.36) | MAPTALDH1A1CHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL10028752 | 0.78 | ALDH1A1 (0.41) | MAPTRAB9AL3MBTL1ALDH1A1CHRNB2 | |
| SCHEMBL7671788 | 0.77 | CHRNB2 (0.39) | MAPTALDH1A1CHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL7754488 | 0.77 | CHRNB2 (0.39) | MAPTALDH1A1CHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL7672435 | 0.75 | CHRNB2 (0.41) | MAPTALDH1A1CHRNB2CHRNA4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271184-B2 | Acyclic and cyclic guanidine- and acetamidine derivatives, their preparation and their use as pesticides, esp. as parasiticides | NOVARTIS ANIMAL HEALTH US, INC. (US) | 2007-09-18 | — | — | US | disclosed |
| EP-1131292-B1 | ACYCLIC AND CYCLIC GUANIDINE- AND ACETAMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PESTICIDES, ESP. AS PARASITICIDES | NOVARTIS AG (CH) | 2006-02-08 | — | — | EP | disclosed |
| US-20040162283-A1 | Acyclic and cyclic guanidine-and acetamidine derivatives, their preparation and their use as pesticides, esp. as parasiticides | GOEBEL THOMAS (DE) | 2004-08-19 | — | — | US | disclosed |
| US-6759407-B2 | A VETERINARY MEDICINE FOR CONTROLLING PARASITES AND PESTS ON ANIMALS | NOVARTIS ANIMAL HEALTH US, INC. | 2004-07-06 | — | — | US | disclosed |
| US-20030203891-A1 | Acyclic and cyclic guanidine- and acetam idine derivatives, their preparation and their use as pesticides, esp. as parasiticides | GOEBEL THOMAS (DE) | 2003-10-30 | — | — | US | disclosed |
| US-6538013-B2 | As a pour-on or spot-on on formulation for controlling parasites such as fleas in warm blooded animals; such as 2,2-dimethylbutyric acid, (1-((6-chloro-pyridin-3-ylmethyl)-ethyl-amino)-2-nitrovinyl)-methyl -carbamoyloxy)-methyl ester | NOVARTIS ANIMAL HEALTH US, INC. | 2003-03-25 | — | — | US | disclosed |
| US-20020028806-A1 | Acyclic and cyclic guanidine-and acetamidine derivatives, their preparation and their use as pesticides, esp. as parasiticides | NOVARTIS AG (CH) | 2002-03-07 | — | — | US | disclosed |
| EP-1131292-A2 | ACYCLIC AND CYCLIC GUANIDINE- AND ACETAMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PESTICIDES, ESP. AS PARASITICIDES | Novartis AG (CH) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000029378-A2 | ACYCLIC AND CYCLIC GUANIDINE- AND ACETAMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PESTICIDES, ESP. AS PARASITICIDES | NOVARTIS AG (CH) | 2000-05-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162283-A1 | Acyclic and cyclic guanidine-and acetamidine derivatives, their preparation and their use as pesticides, esp. as parasiticides | GUCY1A2, GUCY1A1, GUCY1B1 | MAPT 4442/4885RAB9A 356/4885L3MBTL1 533/4885 |
| US-20020028806-A1 | Acyclic and cyclic guanidine-and acetamidine derivatives, their preparation and their use as pesticides, esp. as parasiticides | GUCY1A2, GUCY1A1, GUCY1B1 | MAPT 4411/4885RAB9A 328/4885L3MBTL1 870/4885 |
| US-20030203891-A1 | Acyclic and cyclic guanidine- and acetam idine derivatives, their preparation and their use as pesticides, esp. as parasiticides | CHRM1, GUCY1A2, CHRM2 | MAPT 4668/4885RAB9A 599/4885L3MBTL1 1334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.