Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25256791 | 0.81 | ALDH1A1 (0.60) | LMNAHSD17B10ALDH1A1POLBKMT2A | |
| SCHEMBL25263137 | 0.81 | LMNA (0.60) | LMNAHSD17B10ALDH1A1POLBKMT2A | |
| SCHEMBL394139 | 0.79 | ALDH1A1 (0.46) | HSD17B10ALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL1079494 | 0.74 | ALDH1A1 (0.37) | ALDH1A1POLBKMT2ASMN1; SMN2RAB9A | |
| SCHEMBL29020548 | 0.74 | LMNA (0.48) | LMNAHSD17B10ALDH1A1HCAR2PLA2G2A | |
| SCHEMBL14595072 | 0.71 | L3MBTL1 (0.47) | LMNAHSD17B10ALDH1A1POLBKMT2A | |
| SCHEMBL25252118 | 0.70 | RAB9A (0.47) | LMNAALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL25256365 | 0.70 | ALDH1A1 (0.55) | LMNAALDH1A1POLBKMT2AIGF1R | |
| SCHEMBL13228907 | 0.68 | ALDH1A1 (0.34) | HSD17B10ALDH1A1POLBKMT2AIGF1R | |
| SCHEMBL5415486 | 0.68 | ALDH1A1 (0.45) | LMNAHSD17B10ALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157577-B2 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-20040266843-A1 | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) | SUGEN, INC. | 2004-12-30 | — | — | US | disclosed |
| US-20040204407-A1 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204407-A1 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | DMPK, MAP3K20, PHKG1 | LMNA 2012/4885HSD17B10 2261/4885ALDH1A1 3457/4885 |
| US-20040266843-A1 | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) | CHEK2, CHEK1, ATM | LMNA 2586/4885HSD17B10 2552/4885ALDH1A1 2442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.