Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.59 |
| ▸ | CES1 | P23141 | 2/20 | 0.59 |
| ▸ | DGKA | P23743 | 1/20 | 0.57 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.56 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.55 |
| ▸ | PRKCA | P17252 | 1/20 | 0.55 |
| ▸ | P2RY10 | O00398 | 1/20 | 0.54 |
| ▸ | TERT | O14746 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | FABP4 | P15090 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | PPARD | Q03181 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL540976 | 1.00 | FAAH (0.59) | FAAHCES1DGKALPAR1PRKCE | |
| SCHEMBL2690448 | 0.90 | DGKA (0.62) | FAAHCES1DGKAMAPTHSD17B10 | |
| SCHEMBL21257703 | 0.90 | DGKA (0.62) | FAAHCES1DGKAMAPTHSD17B10 | |
| SCHEMBL2690121 | 0.90 | DGKA (0.62) | FAAHCES1DGKAMAPTHSD17B10 | |
| SCHEMBL835850 | 0.90 | DGKA (0.62) | FAAHCES1DGKAMAPTHSD17B10 | |
| SCHEMBL24961269 | 0.90 | DGKA (0.62) | FAAHCES1DGKAMAPTHSD17B10 | |
| SCHEMBL6509263 | 0.90 | DGKA (0.62) | FAAHCES1DGKAMAPTHSD17B10 | |
| SCHEMBL21257687 | 0.90 | DGKA (0.62) | FAAHCES1DGKAMAPTHSD17B10 | |
| SCHEMBL2692664 | 0.88 | DGKA (0.59) | FAAHCES1DGKAMAPTHSD17B10 | |
| SCHEMBL3663183 | 0.87 | DGKA (0.60) | FAAHDGKAPRKCEPRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414322-B1 | POLYAMINE DERIVATIVES | EGEN INC (US) | 2022-09-14 | — | — | EP | disclosed |
| US-9254334-B2 | Polyamine derivatives | CLSN LABORATORIES, INC. (US) | 2016-02-09 | — | — | US | disclosed |
| CN-104922676-A | POLYAMINE DERIVATIVES | CLSN LAB INC | 2015-09-23 | — | — | CN | disclosed |
| US-20150099000-A1 | Polyamine Derivatives | CLSN LABORATORIES, INC. (US) | 2015-04-09 | — | — | US | disclosed |
| US-8932638-B2 | Polyamine derivatives | CLSN LABORATORIES, INC. (US) | 2015-01-13 | — | — | US | disclosed |
| US-8900621-B2 | Polyamine derivatives | CLSN LABORATORIES, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-20140050775-A1 | Polyamine Derivatives | EGEN, INC. (US) | 2014-02-20 | — | — | US | disclosed |
| US-20130251809-A1 | Polyamine Derivatives | EGEN, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-8460696-B2 | Polyamine derivatives | EGEN, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| EP-2414322-A2 | POLYAMINE DERIVATIVES | Egen, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-20100260817-A1 | Polyamine Derivatives | EGEN, INC. | 2010-10-14 | — | — | US | disclosed |
| WO-2010108108-A2 | POLYAMINE DERIVATIVES | EGEN, INC. (US) | 2010-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130251809-A1 | Polyamine Derivatives | SRM, SMS, SGMS2 | FAAH 4423/4885CES1 3598/4885DGKA 1473/4885 |
| US-20150099000-A1 | Polyamine Derivatives | SRM, SMS, SGMS2 | FAAH 4423/4885CES1 3598/4885DGKA 1473/4885 |
| US-20100260817-A1 | Polyamine Derivatives | SRM, SMS, SGMS2 | FAAH 4423/4885CES1 3598/4885DGKA 1473/4885 |
| US-20140050775-A1 | Polyamine Derivatives | SRM, SMS, SGMS2 | FAAH 4423/4885CES1 3598/4885DGKA 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.