Water

Water

SCHEMBL5409123

C1CN2CCC1CC2.O

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL1542414 1.00 CHRNA7 (0.32)
SCHEMBL18960 0.96
SCHEMBL538360 0.92
Hydrochloric Acid SCHEMBL353996 0.92
Fluoride SCHEMBL8813655 0.92
Fluoride SCHEMBL2112417 0.92 CHRNA7 (0.32)
Iodide SCHEMBL3277614 0.92
SCHEMBL9232705 0.92
Charcoal, Activated SCHEMBL230089 0.92
SCHEMBL6735678 0.92

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4559918-A2 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Genzyme Corporation (US) 2025-05-28 EP disclosed
EP-3673906-B1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORP (US) 2025-05-14 EP disclosed
CN-117679415-A Glucoamide synthase inhibitors 建新公司 2024-03-12 CN disclosed
US-20220409595-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORPORATION 2022-12-29 US disclosed
CN-108290747-B Synthesis of molecular sieve SSZ-105 雪佛龙美国公司 2021-06-11 CN disclosed
EP-3079695-B1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORP (US) 2021-03-17 EP disclosed
CN-107080747-B Glucosylceramide synthase inhibitors 建新公司 2021-02-26 CN disclosed
EP-3673906-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Genzyme Corporation (US) 2020-07-01 EP disclosed
EP-3386918-B1 SYNTHESIS OF MOLECULAR SIEVE SSZ-105 CHEVRON USA INC (US) 2020-03-11 EP disclosed
US-20200048266-A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORP (US) 2020-02-13 US disclosed
WO-2014007874-A1 METHOD FOR PREPARING HIGH-SILICA LEV-TYPE ZEOLITES CHEVRON U.S.A. INC. (US) 2014-01-09 WO disclosed
CN-102928527-A Method for measuring optical purity of R-3-quinuclidine alcohol DISHA PHARMACEUTICAL GROUP CO 2013-02-13 CN disclosed
WO-2012129084-A2 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORPORATION (US) 2012-09-27 WO disclosed
US-7208137-B2 Maintaining reaction mixture comprising zeolite which is an active source of aluminum oxide, active source of alkali metal oxide, an active source of an oxide of a tetravalent element, and an organic template under condition to form crystals CHEVRON U.S.A. INC. (US) 2007-04-24 US disclosed
US-20050135999-A1 Aluminum-containing zeolite with IFR structure CHEVRON U.S.A. INC. 2005-06-23 US disclosed
US-6821502-B2 MAINTAINING REACTION MIXTURE COMPRISING ZEOLITE WHICH IS AN ACTIVE SOURCE OF ALUMINUM OXIDE, ACTIVE SOURCE OF ALKALI METAL OXIDE, AN ACTIVE SOURCE OF AN OXIDE OF A TETRAVALENT ELEMENT, AND AN ORGANIC TEMPLATE UNDER CONDITION TO FORM CRYSTALS CHEVRON U.S.A. INC. 2004-11-23 US disclosed
WO-2004041722-A2 METHOD OF MAKING ALUMINUM-CONTAINING ZEOLITE WITH IFR STRUCTURE CHEVRON U.S.A. INC. (US) 2004-05-21 WO disclosed
US-20030232007-A1 Method of making aluminum-containing zeolite with IFR structure CHEVRON U.S.A., INC. 2003-12-18 US disclosed
EP-0345330-A1 PROCESSES FOR THE PRODUCTION OF AMINES UNION CARBIDE CORPORATION (US) 1989-12-13 EP disclosed
WO-1989005810-A1 PROCESSES FOR THE PRODUCTION OF AMINES UNION CARBIDE CORPORATION (US) 1989-06-29 WO disclosed