Sugi Predict

Sugi Predict / Compounds / SCHEMBL541591

SCHEMBL541591

SCHEMBL541591

COc1ccc(Cl)cc1O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.59
▸ LMNA P02545 2/20 0.59
▸ NR1I2 O75469 1/20 0.59
▸ TTR P02766 1/20 0.59
▸ PGR P06401 1/20 0.59
▸ HSP90AA1 P07900 1/20 0.59
▸ ADORA3 P0DMS8 1/20 0.59
▸ HSPA5 P11021 1/20 0.59
▸ HPGD P15428 1/20 0.59
▸ CBR1 P16152 1/20 0.59
▸ TBXA2R P21731 1/20 0.59
▸ SLC6A2 P23975 1/20 0.59
▸ AGTR1 P30556 1/20 0.59
▸ SLC6A3 Q01959 1/20 0.59
▸ ALDH1A1 P00352 2/20 0.52
▸ AOX1 Q06278 1/20 0.52
▸ TSHR P16473 3/20 0.50
▸ CYP3A4 P08684 2/20 0.50
▸ CYP1A2 P05177 2/20 0.50
▸ HSD17B10 Q99714 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31142480 1.00 MAPT (0.59) MAPTLMNANR1I2TTRPGR
SCHEMBL15246783 0.86 SLC6A2 (0.65) MAPTLMNANR1I2TTRPGR
SCHEMBL363972 0.82 MAOB (0.61) HPGDALDH1A1TSHRHSD17B10TDP1
SCHEMBL10540653 0.81 TTR (0.83) MAPTLMNANR1I2TTRPGR
SCHEMBL14157301 0.81 HPGD (0.58) MAPTLMNANR1I2TTRPGR
SCHEMBL18155551 0.80 TUBB4A (0.46) MAPTLMNANR1I2TTRPGR
SCHEMBL31527873 0.79 TUBB4A (0.66) LMNATSHRCYP3A4CYP1A2KMT2A
SCHEMBL27183174 0.79 TUBB4A (0.66) LMNATSHRCYP3A4CYP1A2KMT2A
SCHEMBL29636402 0.78 TRPV4 (0.55) MAPTLMNATTRSLC6A2SLC6A3
SCHEMBL2127233 0.78 TRPV4 (0.55) MAPTLMNATTRSLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250059161-A1 COMPOUNDS AND METHODS FOR MODULATING STAT3 VIVIDION THERAPEUTICS, INC. 2025-02-20 — — US disclosed
WO-2024182693-A1 2-AZASPIRO[3.3]HEPTANE DERIVATIVES AS STAT3 INHIBITORS FOR THE TREATMENT OF CANCER VIVIDION THERAPEUTICS, INC. (US) 2024-09-06 — — WO disclosed
CN-117820101-A Amplified preparation method of Edwan sweet 上海再启生物技术有限公司 2024-04-05 — — CN disclosed
US-20240092744-A1 TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF THE NATIONAL INSTITUTES OF PHARMACEUTICAL R&D CO., LTD (CN) 2024-03-21 — — US disclosed
CN-114981275-B Tricyclic compound, preparation method and medical application thereof 中国医药研究开发中心有限公司 2023-12-19 — — CN disclosed
EP-4273150-A1 TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF The National Institutes of Pharmaceutical R&D Co., Ltd (CN) 2023-11-08 — — EP disclosed
EP-4273150-A1 TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF The National Institutes of Pharmaceutical R&D Co., Ltd (CN) 2023-11-08 — — EP disclosed
CN-114981275-A Tricyclic compound, preparation method and medical application thereof 中国医药研究开发中心有限公司 2022-08-30 — — CN disclosed
US-11395829-B2 Inhibitors of metallo-beta-lactamases produced by multidrug-resistant bacteria MYONGJI UNIVERSITY INDUSTRY AND ACADEMIA COOPERATION FOUNDATION (KR) 2022-07-26 — — US disclosed
WO-2022148717-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2022-07-14 — — WO disclosed
US-4540834-A HYDRODECHLORINATION OF POLYCHLOROPHENOL, HYDRIOTIC ACID RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1985-09-10 — — US disclosed
US-4410738-A Preparation of meta-chlorophenols by selective hydrodechlorination of polychlorophenols RHONE-POULENC INDUSTRIES (FR) 1983-10-18 — — US disclosed
US-4410737-A Preparation of meta-chlorophenols by selective hydrodechlorination of polychlorophenols RHONE-POULENC INDUSTRIES (FR) 1983-10-18 — — US disclosed
US-4410739-A LEWIS ACID, NOBLE METAL CATALYST RHONE-POULENC INDUSTRIES (FR) 1983-10-18 — — US disclosed
US-4061642-A AZO DYE INTERMEDIATES CASSELLA FARBWERKE MAINKUR AG (DT) 1977-12-06 — — US disclosed
US-3980659-A INSECTICIDES, INTERMEDIATES FOR AZO DYES CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-09-14 — — US disclosed
US-3956294-A AZO DYES, PESTICIDES, ANALEPTICS, ANALGESICS, DIURETICS CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-05-11 — — US disclosed
US-3954782-A 2,6-Hydrazino-3-pyridine carboxyamides CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-05-04 — — US disclosed
US-3947463-A Certain 2-amino-nicotinonitrile derivatives CASSELLA FARBWERKE MAINKUR AG (DT) 1976-03-30 — — US disclosed
US-3946024-A INTERMEDIATES FOR AZO DYES CASSELLA FARBWERKE MAINKUR AG (DT) 1976-03-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250059161-A1 COMPOUNDS AND METHODS FOR MODULATING STAT3 STAT3, JAK2, STAT1 MAPT 4261/4885LMNA 4098/4885NR1I2 2767/4885
US-20240092744-A1 TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF GOT2, HADH, CYP4A11 MAPT 2211/4885LMNA 728/4885NR1I2 999/4885
US-11395829-B2 Inhibitors of metallo-beta-lactamases produced by multidrug-resistant bacteria MANBA, MGAM, GUSB MAPT 3506/4885LMNA 2275/4885NR1I2 488/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.