Sugi Predict

Sugi Predict / Compounds / SCHEMBL5417403

SCHEMBL5417403

SCHEMBL5417403

CCCCCC1=NNC(=O)CC1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.44
▸ NPY1R P25929 1/20 0.44
▸ NPY2R P49146 1/20 0.44
▸ MAPT P10636 2/20 0.38
▸ ALDH1A1 P00352 1/20 0.35
▸ DHFR P00374 1/20 0.35
▸ ALOX5 P09917 2/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ ACHE P22303 1/20 0.33
▸ BACE1 P56817 1/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ PKM P14618 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ GPR84 Q9NQS5 7/20 0.33
▸ KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16016955 0.87 LMNA (0.39) LMNANPY1RNPY2RMAPTALDH1A1
SCHEMBL10846920 0.86 LMNA (0.41) LMNANPY1RNPY2RMAPTALDH1A1
SCHEMBL4887906 0.83 GAA (0.41) LMNANPY1RNPY2RMAPTALDH1A1
SCHEMBL19710210 0.78 — —
SCHEMBL5566058 0.77 GAA (0.42) LMNANPY1RNPY2RMAPTALDH1A1
SCHEMBL16019686 0.76 ALDH1A1 (0.48) MAPTALDH1A1DHFRSMN1; SMN2
SCHEMBL18556771 0.75 SMYD3 (0.37) LMNANPY1RNPY2RMAPTALDH1A1
SCHEMBL3644791 0.75 SMN1; SMN2 (0.36) LMNANPY1RNPY2RMAPTALDH1A1
SCHEMBL9415626 0.74 LMNA (0.35) LMNANPY1RNPY2RMAPTALDH1A1
SCHEMBL13995848 0.73 ALDH1A1 (0.40) LMNANPY1RNPY2RMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0117403-B1 6-(ACYLAMINOARYL)-3(2H)-PYRIDAZINONE DERIVATIVES, THEIR PREPARATION AND USE BASF Aktiengesellschaft (DE) 1988-06-01 — — EP claimed
EP-0089528-B1 6-ARYL-4,5-DIHYDRO-3(2H)-PYRIDAZINONES, THEIR PREPARATION AND USE BASF Aktiengesellschaft (DE) 1987-05-27 — — EP claimed
US-4544562-A 6-Aryl-4,5-dihydro-3(2H)-pyridazinones, and their use as anti-hypertensive and anti-thrombocyte agents BASF AKTIENGESELLSCHAFT (DE) 1985-10-01 — — US claimed
EP-0089528-A1 6-Aryl-4,5-dihydro-3(2H)-pyridazinones, their preparation and use BASF Aktiengesellschaft (DE) 1983-09-28 — — EP claimed
JP-58167573-A — — None — — JP disclosed
US-20210300954-A1 IONIC TAGS FOR SYNTHESIS OF OLIGORIBONUCLEOTIDES THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV (CA) 2021-09-30 — — US disclosed
US-11014948-B2 Ionic tags for synthesis of oligoribonucleotides THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2021-05-25 — — US disclosed
US-9920084-B2 Ionic tags for synthesis of oligoribonucleotides THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2018-03-20 — — US disclosed
US-9920084-B2 Ionic tags for synthesis of oligoribonucleotides THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2018-03-20 — — US disclosed
US-20140256926-A1 Ionic Tags for Synthesis of Oligoribonucleotides HONG KONG POLYTECHNIC UNIVERSITY (HK) 2014-09-11 — — US disclosed
US-20070060605-A1 Compositions and methods for inhibiting platelet activation and thrombosis FLAUMENHAFT ROBERT C 2007-03-15 — — US disclosed
US-7166612-B2 Methods for reducing platelet activation platelet aggregaton or thrombosis BETH ISRAEL DEACONESS MEDICAL CENTER (US) 2007-01-23 — — US disclosed
EP-0089528-A1 6-Aryl-4,5-dihydro-3(2H)-pyridazinones, their preparation and use BASF Aktiengesellschaft (DE) 1983-09-28 — — EP disclosed
EP-0086301-A1 Thiadiazine, oxadiazine and triazine derivatives and pharmaceutical compositions containing them IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-08-24 — — EP disclosed
EP-0085227-A1 Thiadiazine derivatives, and pharmaceutical compositions containing them IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-08-10 — — EP disclosed
EP-0081906-A1 Pharmaceutically-active pyridylvinylpyridazinones IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-06-22 — — EP disclosed
EP-0080296-A1 Pharmaceutically active phenyl-thia-, oxa- or triazinones IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-06-01 — — EP disclosed
EP-0052442-A1 Heterocyclic compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-05-26 — — EP disclosed
US-4271163-A HYPOTENSIVE AGENTS BASF AKTIENGESELLSCHAFT (DE) 1981-06-02 — — US disclosed
US-4092311-A Hypotensive alkyl-3-[6-(aryl)-3-pyridazinyl]-carbazates AMERICAN CYANAMID COMPANY (US) 1978-05-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070060605-A1 Compositions and methods for inhibiting platelet activation and thrombosis PLA2G7, PLTP, PLAAT2 LMNA 2976/4885NPY1R 3142/4885NPY2R 3485/4885
US-11014948-B2 Ionic tags for synthesis of oligoribonucleotides RNGTT, OSTC, DTYMK LMNA 2711/4885NPY1R 1551/4885NPY2R 1435/4885
US-20210300954-A1 IONIC TAGS FOR SYNTHESIS OF OLIGORIBONUCLEOTIDES RNGTT, OSTC, DTYMK LMNA 2711/4885NPY1R 1551/4885NPY2R 1435/4885
US-20140256926-A1 Ionic Tags for Synthesis of Oligoribonucleotides RNGTT, OSTC, OSGEP LMNA 2643/4885NPY1R 1618/4885NPY2R 1545/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.