Sugi Predict

Sugi Predict / Compounds / SCHEMBL542034

SCHEMBL542034

SCHEMBL542034

CC1(C)[C@@H]2CC[C@@]1(C)[C@@H](N)C2

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.39
▸ EPHX2 P34913 6/20 0.38
▸ SIGMAR1 Q99720 3/20 0.37
▸ GRIN2D O15399 1/20 0.37
▸ GRIN3B O60391 1/20 0.37
▸ GRIN1 Q05586 1/20 0.37
▸ GRIN2A Q12879 1/20 0.37
▸ GRIN2B Q13224 1/20 0.37
▸ GRIN2C Q14957 1/20 0.37
▸ GRIN3A Q8TCU5 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ CXCR3 P49682 1/20 0.36
▸ MAPT P10636 1/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29159126 1.00 ALDH1A1 (0.39) ALDH1A1EPHX2SIGMAR1GRIN2DGRIN3B
SCHEMBL12610926 1.00 ALDH1A1 (0.39) ALDH1A1EPHX2SIGMAR1GRIN2DGRIN3B
SCHEMBL838670 1.00 ALDH1A1 (0.39) ALDH1A1EPHX2SIGMAR1GRIN2DGRIN3B
SCHEMBL12024467 1.00 ALDH1A1 (0.39) ALDH1A1EPHX2SIGMAR1GRIN2DGRIN3B
SCHEMBL6389608 1.00 ALDH1A1 (0.39) ALDH1A1EPHX2SIGMAR1GRIN2DGRIN3B
SCHEMBL1527311 1.00 ALDH1A1 (0.39) ALDH1A1EPHX2SIGMAR1GRIN2DGRIN3B
SCHEMBL14367329 1.00 ALDH1A1 (0.39) ALDH1A1EPHX2SIGMAR1GRIN2DGRIN3B
SCHEMBL18543456 1.00 ALDH1A1 (0.39) ALDH1A1EPHX2SIGMAR1GRIN2DGRIN3B
SCHEMBL1933742 1.00 ALDH1A1 (0.39) ALDH1A1EPHX2SIGMAR1GRIN2DGRIN3B
SCHEMBL838671 1.00 ALDH1A1 (0.39) ALDH1A1EPHX2SIGMAR1GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1928840-B1 1H-Pyrazole-4-carboxamides, their preparation and their use as 11-beta-hydroxysteroid dehydrogenase inhibitors HOFFMANN LA ROCHE (CH) 2011-08-10 — — EP claimed
US-7345058-B2 (1-Methyl-5-phenyl-1H-pyrazol-4-yl)-(trans-octahydro-isoquinolin-2-yl)methanone; 11 beta -hydroxysteroid dehydrogenase inhibitor; upregulation of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase); antidiabetic agent; type II diabetes mellitus and metabolic syndrome HOFFMANN-LA ROCHE INC. (US) 2008-03-18 — — US claimed
US-20060223852-A1 Pyrazoles GILLESPIE PAUL 2006-10-05 — — US claimed
US-12582641-B2 Sulfur-containing compound based on glutarimide skeleton and application thereof SHANGHAITECH UNIVERSITY (CN) 2026-03-24 — — US disclosed
CN-117616011-A Inhibitors of transglutaminase 策迪拉有限公司 2024-02-27 — — CN disclosed
CN-117561241-A Inhibitors of transglutaminase 策迪拉有限公司 2024-02-13 — — CN disclosed
CN-113372327-B Glutarimide skeleton-based compound and application thereof 上海科技大学 2023-07-18 — — CN disclosed
WO-2023110138-A1 INHIBITORS OF TRANSGLUTAMINASES ZEDIRA GMBH (DE) 2023-06-22 — — WO disclosed
EP-4192814-A1 INHIBITORS OF TRANSGLUTAMINASES Zedira GmbH (DE) 2023-06-14 — — EP disclosed
EP-4192813-A1 INHIBITORS OF TRANSGLUTAMINASES Zedira GmbH (DE) 2023-06-14 — — EP disclosed
CN-111606883-B Sulfur-containing compound based on glutarimide skeleton and application thereof 上海科技大学 2023-05-09 — — CN disclosed
WO-2007071662-A1 4,5-DIHYDRO- (1H)-PYRAZOLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR MODULATORS SOLVAY PHARMACEUTICALS B.V. (NL) 2007-06-28 — — WO disclosed
US-20070142362-A1 4,5-Dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators SOLVAY PHARMACEUTICALS B.V. 2007-06-21 — — US disclosed
WO-2006106052-A1 PYRAZOLES F. HOFFMANN-LA ROCHE AG (CH) 2006-10-12 — — WO disclosed
US-20060223852-A1 Pyrazoles GILLESPIE PAUL 2006-10-05 — — US disclosed
US-20060194779-A1 1H-imidazole derivatives as cannabinoid CB2 receptor modulators ABBVIE B.V. (NL) 2006-08-31 — — US disclosed
WO-2006087355-A1 1H-IMIDIAZOLE DERIVATIVES AS CANNABINOID CB2 RECEPTOR MODULATORS SOLVAY PHARMACEUTICALS B.V. (NL) 2006-08-24 — — WO disclosed
EP-1664005-A1 THIAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS Solvay Pharmaceuticals B.V. (NL) 2006-06-07 — — EP disclosed
WO-2005028456-A1 THIAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS SOLVAY PHARMACEUTICALS B.V. (NL) 2005-03-31 — — WO disclosed
US-20050065189-A1 Thiazole derivatives as cannabinoid receptor modulators SOLVAY PHARMACEUTICALS B.V. 2005-03-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12582641-B2 Sulfur-containing compound based on glutarimide skeleton and application thereof SUCNR1, SRD5A1, GLS ALDH1A1 697/4885EPHX2 3929/4885SIGMAR1 506/4885
US-20070142362-A1 4,5-Dihydro-(1H)-pyrazole derivatives as cannabinoid CB1 receptor modulators CNR1, CNR2, GPR55 ALDH1A1 1889/4885EPHX2 1358/4885SIGMAR1 349/4885
US-20050065189-A1 Thiazole derivatives as cannabinoid receptor modulators CNR1, CNR2, NPY1R ALDH1A1 1743/4885EPHX2 891/4885SIGMAR1 138/4885
US-20060223852-A1 Pyrazoles GPR119, PDK2, PC ALDH1A1 333/4885EPHX2 3399/4885SIGMAR1 2649/4885
US-20060194779-A1 1H-imidazole derivatives as cannabinoid CB2 receptor modulators CNR1, CNR2, HRH4 ALDH1A1 1715/4885EPHX2 1310/4885SIGMAR1 419/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.