Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 14/20 | 0.51 |
| ▸ | MMP2 | P08253 | 12/20 | 0.51 |
| ▸ | CA12 | O43570 | 4/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | MMP3 | P08254 | 6/20 | 0.49 |
| ▸ | MMP1 | P03956 | 5/20 | 0.49 |
| ▸ | MMP14 | P50281 | 4/20 | 0.49 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | MMP8 | P22894 | 5/20 | 0.46 |
| ▸ | MMP12 | P39900 | 3/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8281070 | 0.85 | HSP90AA1 (0.47) | MMP9MMP2MMP3MMP1MMP13 | |
| SCHEMBL54973 | 0.82 | MMP2 (0.59) | MMP9MMP2CA12CA9MMP3 | |
| SCHEMBL48808 | 0.82 | MMP2 (0.59) | MMP9MMP2CA12CA9MMP3 | |
| SCHEMBL48807 | 0.82 | MMP2 (0.59) | MMP9MMP2CA12CA9MMP3 | |
| SCHEMBL4385516 | 0.82 | MMP2 (0.59) | MMP9MMP2CA12CA9MMP3 | |
| SCHEMBL3859738 | 0.73 | ADAM17 (0.79) | ADAM17 | |
| SCHEMBL3859743 | 0.73 | ADAM17 (0.79) | ADAM17 | |
| SCHEMBL49184 | 0.72 | MMP2 (0.63) | MMP9MMP2MMP3MMP1MMP14 | |
| SCHEMBL49193 | 0.72 | MMP2 (0.63) | MMP9MMP2MMP3MMP1MMP14 | |
| SCHEMBL49185 | 0.72 | MMP2 (0.63) | MMP9MMP2MMP3MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129406-B2 | Nonpeptide inhibitors of matrix metalloproteinases | SOUTHERN RESEARCH INSTITUTE (US) | 2012-03-06 | — | — | US | disclosed |
| US-20080312329-A1 | Nonpeptide Inhibitors of Matrix Metalloproteinases | SOUTHERN RESEARCH INSTITUTE (US) | 2008-12-18 | — | — | US | disclosed |
| US-20080312329-A1 | Nonpeptide Inhibitors of Matrix Metalloproteinases | SOUTHERN RESEARCH INSTITUTE (US) | 2008-12-18 | — | — | US | disclosed |
| WO-2005092844-A1 | NONPEPTIDE INHIBITORS OF MATRIX METALLOPROTEINASES | SOUTHERN RESEARCH INSTITUTE (US) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312329-A1 | Nonpeptide Inhibitors of Matrix Metalloproteinases | MMP1, MMP3, MMP10 | MMP9 7/4885MMP2 11/4885CA12 2614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.