Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | LDHB | P07195 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 3/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31307947 | 0.87 | TSHR (0.61) | TSHRLMNAPTPN1BCL2PTPN2 | |
| SCHEMBL566628 | 0.85 | RXRA (0.47) | TSHRRXRAPPARGPTPN1 | |
| SCHEMBL8984332 | 0.80 | ACE2 (0.49) | TSHRRXRAPPARGPTPN1 | |
| SCHEMBL14922850 | 0.80 | ALDH1A1 (0.48) | TSHRRXRAPPARGPTPN1 | |
| SCHEMBL6493687 | 0.79 | TSHR (0.56) | TSHRLDHALDHBRXRALMNA | |
| SCHEMBL27510579 | 0.79 | TSHR (0.56) | TSHRLDHALDHBRXRALMNA | |
| SCHEMBL20362631 | 0.79 | ALOX5 (0.61) | LDHALDHBMTNR1AMTNR1BBCL2 | |
| SCHEMBL8095678 | 0.78 | CALM1 (0.44) | LDHALDHBMTNR1AMTNR1BLMNA | |
| SCHEMBL6772376 | 0.78 | TSHR (0.69) | TSHRLMNAPTPN1BCL2PTPN2 | |
| SCHEMBL9651071 | 0.77 | MEN1 (0.59) | TSHRPTPN1BCL2PTPN2PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101595096-B | Substituted carbinol compounds | KOWA CO JP | 2012-06-27 | — | — | CN | disclosed |
| US-8168666-B2 | Substituted carbinol compound | KOWA COMPANY, LTD. (JP) | 2012-05-01 | — | — | US | disclosed |
| EP-2098515-B1 | SUBSTITUTED CARBINOL COMPOUND | KOWA CO (JP) | 2012-02-08 | — | — | EP | disclosed |
| US-20100063119-A1 | SUBSTITUTED CARBINOL COMPOUND | KOWA COMPANY, LTD. (JP) | 2010-03-11 | — | — | US | disclosed |
| CN-101595096-A | Substituted carbinol compounds | KOWA CO (JP) | 2009-12-02 | — | — | CN | disclosed |
| EP-2098515-A1 | SUBSTITUTED CARBINOL COMPOUND | Kowa Company. Ltd. (JP) | 2009-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063119-A1 | SUBSTITUTED CARBINOL COMPOUND | NR1H2, NR1H3, CYP46A1 | TSHR 2854/4885LDHA 3953/4885LDHB 3353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.