Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | CFTR | P13569 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8822600 | 0.84 | L3MBTL1 (0.58) | L3MBTL1PKMALDH1A1HSD17B10CFTR | |
| SCHEMBL9086314 | 0.84 | L3MBTL1 (0.51) | L3MBTL1PKMALDH1A1HSD17B10CFTR | |
| SCHEMBL8832101 | 0.83 | KDM4E (0.58) | L3MBTL1PKMALDH1A1HSD17B10KDM4E | |
| SCHEMBL8831739 | 0.80 | L3MBTL1 (0.53) | L3MBTL1PKMALDH1A1HSD17B10KDM4E | |
| SCHEMBL9522884 | 0.80 | L3MBTL1 (0.53) | L3MBTL1PKMALDH1A1HSD17B10CFTR | |
| SCHEMBL543367 | 0.79 | ALDH1A1 (0.54) | L3MBTL1PKMALDH1A1KDM4EMAPK1 | |
| SCHEMBL9524381 | 0.79 | L3MBTL1 (0.52) | L3MBTL1PKMALDH1A1HSD17B10KDM4E | |
| SCHEMBL9524388 | 0.79 | L3MBTL1 (0.52) | L3MBTL1PKMALDH1A1HSD17B10KDM4E | |
| SCHEMBL8831608 | 0.79 | L3MBTL1 (0.55) | L3MBTL1PKMALDH1A1HSD17B10KDM4E | |
| SCHEMBL9523762 | 0.78 | L3MBTL1 (0.51) | L3MBTL1PKMALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141150-B1 | BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2013-12-11 | — | — | EP | disclosed |
| US-8110585-B2 | Bicyclic compound and pharmaceutical use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-07 | — | — | US | disclosed |
| US-8110585-B2 | Bicyclic compound and pharmaceutical use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-07 | — | — | US | disclosed |
| US-20100130538-A1 | BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2010-05-27 | — | — | US | disclosed |
| US-20100130538-A1 | BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2010-05-27 | — | — | US | disclosed |
| CN-101687810-A | Bicyclic compound and pharmaceutical use thereof | TAKEDA PHARMACEUTICAL | 2010-03-31 | — | — | CN | disclosed |
| EP-2141150-A1 | BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-01-06 | — | — | EP | disclosed |
| US-5658854-A | Acylated aminophenylsulfonylureas; preparation and use as herbicides and plant growth regulators | HOECHST SCHERING AGREVO GMBH (DE) | 1997-08-19 | — | — | US | disclosed |
| CN-1033354-C | Compositions of 7-substituted-benzo-1,2,3-thiadiazole derivetes | CIBA GEIGY AG (CH) | 1996-11-27 | — | — | CN | disclosed |
| CN-1033299-C | Method for immured plant from disease | CIBA GEIGY AG (CH) | 1996-11-20 | — | — | CN | disclosed |
| CN-1068932-A | Make plant have the method for immunity to disease | CIBA GEIGY AG (CH) | 1993-02-17 | — | — | CN | disclosed |
| CN-1068471-A | Compositions of 7-substituted benzo-1, 2, 3-thiadiazole derivatives | CIBA GEIGY AG (CH) | 1993-02-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130538-A1 | BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | MTNR1A, MTNR1B, XDH | L3MBTL1 3605/4885PKM 3083/4885ALDH1A1 1431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.