Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10831867 | 0.89 | HPGD (0.55) | ALDH1A1L3MBTL1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL9087640 | 0.85 | TSHR (0.51) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9086771 | 0.84 | ALDH1A1 (0.47) | ALDH1A1PKML3MBTL1MAPTMAPK1 | |
| SCHEMBL9087431 | 0.83 | PKM (0.46) | ALDH1A1PKML3MBTL1MAPTMAPK1 | |
| SCHEMBL1548540 | 0.83 | POLB (0.56) | ALDH1A1PKML3MBTL1MAPTMAPK1 | |
| SCHEMBL9833207 | 0.81 | HPGD (0.53) | ALDH1A1L3MBTL1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8822600 | 0.80 | L3MBTL1 (0.58) | ALDH1A1PKML3MBTL1MAPTMAPK1 | |
| SCHEMBL15689324 | 0.80 | CACNA1C (0.52) | ALDH1A1PKML3MBTL1MAPTMAPK1 | |
| SCHEMBL543449 | 0.79 | L3MBTL1 (0.56) | ALDH1A1PKML3MBTL1MAPTMAPK1 | |
| SCHEMBL8832101 | 0.79 | KDM4E (0.58) | ALDH1A1PKML3MBTL1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141150-B1 | BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2013-12-11 | — | — | EP | disclosed |
| US-8110585-B2 | Bicyclic compound and pharmaceutical use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-07 | — | — | US | disclosed |
| US-8110585-B2 | Bicyclic compound and pharmaceutical use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-07 | — | — | US | disclosed |
| US-20100130538-A1 | BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2010-05-27 | — | — | US | disclosed |
| US-20100130538-A1 | BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2010-05-27 | — | — | US | disclosed |
| CN-101687810-A | Bicyclic compound and pharmaceutical use thereof | TAKEDA PHARMACEUTICAL | 2010-03-31 | — | — | CN | disclosed |
| EP-2141150-A1 | BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-01-06 | — | — | EP | disclosed |
| CN-1051305-C | Acylated aminophenyl urea compounds, their preparation and their use as herbicides and plant-growth regulators | HOECHST SCHERING AGREVO GMBH (DE) | 2000-04-12 | — | — | CN | disclosed |
| US-5658854-A | Acylated aminophenylsulfonylureas; preparation and use as herbicides and plant growth regulators | HOECHST SCHERING AGREVO GMBH (DE) | 1997-08-19 | — | — | US | disclosed |
| CN-1033354-C | Compositions of 7-substituted-benzo-1,2,3-thiadiazole derivetes | CIBA GEIGY AG (CH) | 1996-11-27 | — | — | CN | disclosed |
| CN-1033299-C | Method for immured plant from disease | CIBA GEIGY AG (CH) | 1996-11-20 | — | — | CN | disclosed |
| US-5523311-A | CARBONYLOXY OR THIOCARBONYL-BENZO-1,2,3-THIADIAZOLE DERIVATIVES USED AS CHEMICAL ACTIVATOR TO STIMULATE PLANTS CAPACITY TO DEFEND ITSELF AGAINST MICROBIAL INFECTIONS | CIBA-GEIGY CORPORATION (US) | 1996-06-04 | — | — | US | disclosed |
| US-5190928-A | Benzo-1,2,3-thiadiazoles | CIBA-GEIGY CORPORATION (US) | 1993-03-02 | — | — | US | disclosed |
| CN-1068932-A | Make plant have the method for immunity to disease | CIBA GEIGY AG (CH) | 1993-02-17 | — | — | CN | disclosed |
| CN-1068471-A | Compositions of 7-substituted benzo-1, 2, 3-thiadiazole derivatives | CIBA GEIGY AG (CH) | 1993-02-03 | — | — | CN | disclosed |
| US-4931581-A | CHEMICAL INTERMEDIATES FOR 1,2,3-BENZOTHIADIAZOLE DERIVATIVES | CIBA-GEIGY CORPORATION (US) | 1990-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130538-A1 | BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF | MTNR1A, MTNR1B, XDH | ALDH1A1 1431/4885PKM 3083/4885L3MBTL1 3605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.