SCHEMBL5437358

SCHEMBL5437358

CN1C(=O)CC(=O)N(c2ccccc2)C1=O

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRK1 P41145 1/20 0.56
PDE4D Q08499 1/20 0.56
HPGD P15428 2/20 0.50
GAA P10253 6/20 0.47
TLR9 Q9NR96 2/20 0.47
PKM P14618 1/20 0.47
MEN1 O00255 6/20 0.46
KMT2A Q03164 6/20 0.46
MAPT P10636 3/20 0.46
ALDH1A1 P00352 4/20 0.46
MGLL Q99685 1/20 0.42
KDM4E B2RXH2 2/20 0.41
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
USP2 O75604 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL437784 0.86 HPGD (0.59) OPRK1PDE4DHPGDGAATLR9
SCHEMBL11648431 0.85 POLB (0.48) OPRK1PDE4DHPGDPKMMEN1
SCHEMBL5443754 0.85 ELANE (0.57) OPRK1PDE4DHPGDGAATLR9
SCHEMBL11785882 0.83 MAPT (0.44) OPRK1PDE4DGAAMEN1KMT2A
SCHEMBL17358738 0.83 CTSG (0.61) OPRK1PDE4DHPGDGAATLR9
SCHEMBL9565728 0.83 OPRK1 (0.55) OPRK1PDE4DHPGDMEN1KMT2A
SCHEMBL9565725 0.83 MEN1 (0.49) OPRK1PDE4DGAAMEN1KMT2A
SCHEMBL12013775 0.82 CA12 (0.59) OPRK1PDE4DHPGDGAAMEN1
SCHEMBL30087538 0.81 OPRK1 (0.70) OPRK1PDE4DHPGDGAATLR9
SCHEMBL11559256 0.81 OPRK1 (0.70) OPRK1PDE4DHPGDGAATLR9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070130702-A1 Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative L'OREAL S.A. 2007-06-14 US claimed
US-3995021-A DIAZOTIZATION OF AN AMINO PHENYL SUBSTITUTED HAPTEN BIOLOGICAL DEVELOPMENTS, INC. (US) 1976-11-30 US claimed
US-12163084-B2 Monoazo dichroic dye compound, polarizing plate composition comprising same, polarizing plate formed therefrom, and optical device comprising same LG CHEM, LTD. (KR) 2024-12-10 US disclosed
US-20230340331-A1 MONOAZO DICHROIC DYE COMPOUND, POLARIZING PLATE COMPOSITION COMPRISING SAME, POLARIZING PLATE FORMED THEREFROM, AND OPTICAL DEVICE COMPRISING SAME LG CHEM, LTD. (KR) 2023-10-26 US disclosed
US-20230340331-A1 MONOAZO DICHROIC DYE COMPOUND, POLARIZING PLATE COMPOSITION COMPRISING SAME, POLARIZING PLATE FORMED THEREFROM, AND OPTICAL DEVICE COMPRISING SAME LG CHEM, LTD. (KR) 2023-10-26 US disclosed
US-20230340331-A1 MONOAZO DICHROIC DYE COMPOUND, POLARIZING PLATE COMPOSITION COMPRISING SAME, POLARIZING PLATE FORMED THEREFROM, AND OPTICAL DEVICE COMPRISING SAME LG CHEM, LTD. (KR) 2023-10-26 US disclosed
CN-116171394-A Monoazo dichroic dye compound, polarizing plate composition comprising the same, polarizing plate formed therefrom, and optical device comprising the same 株式会社LG化学 2023-05-26 CN disclosed
WO-2022139099-A1 MONOAZO DICHROIC DYE COMPOUND, POLARIZING PLATE COMPOSITION COMPRISING SAME, POLARIZING PLATE FORMED THEREFROM, AND OPTICAL DEVICE COMPRISING SAME 주식회사 엘지화학 2022-06-30 WO disclosed
WO-2021145582-A1 MONO-AZO DICHROIC DYE COMPOUND, POLARIZING PLATE COMPOSITION COMPRISING SAME, POLARIZING PLATE FORMED THEREFROM, AND OPTICAL DEVICE COMPRISING SAME 주식회사 엘지화학 2021-07-22 WO disclosed
WO-2021145582-A1 MONO-AZO DICHROIC DYE COMPOUND, POLARIZING PLATE COMPOSITION COMPRISING SAME, POLARIZING PLATE FORMED THEREFROM, AND OPTICAL DEVICE COMPRISING SAME 주식회사 엘지화학 2021-07-22 WO disclosed
CN-107613965-A For reducing the method and composition of gastric emptying 普渡制药公司 2018-01-19 CN disclosed
US-4714838-A USING LASER AS SOURCE OF COHERENT LIGHT MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1987-12-22 US disclosed
US-4382983-A PARTIALLY HYDROLYZED SILOXANE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-05-10 US disclosed
US-4259488-A Bis-isoindoline pigments CIBA-GEIGY CORPORATION (US) 1981-03-31 US disclosed
US-4097475-A FOR POLYESTERS AND BLENDS WITH CELLULOSE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1978-06-27 US disclosed
US-4062845-A POLYESTERS BASF AKTIENGESELLSCHAFT (DT) 1977-12-13 US disclosed
US-4062836-A YELLOW CIBA-GEIGY CORPORATION (US) 1977-12-13 US disclosed
US-4009165-A POLYESTERS BASF AKTIENGESELLSCHAFT (DT) 1977-02-22 US disclosed
US-3995021-A DIAZOTIZATION OF AN AMINO PHENYL SUBSTITUTED HAPTEN BIOLOGICAL DEVELOPMENTS, INC. (US) 1976-11-30 US disclosed
US-3980651-A Water-insoluble barbituric acid-substituted naphthalactam dyestuff BAYER AKTIENGESELLSCHAFT (DT) 1976-09-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12163084-B2 Monoazo dichroic dye compound, polarizing plate composition comprising same, polarizing plate formed therefrom, and optical device comprising same ORMDL3, WEE1, WEE2 OPRK1 3026/4885PDE4D 4458/4885HPGD 3574/4885
US-20070130702-A1 Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative KRT18, NDUFB5, NDUFB7 OPRK1 1832/4885PDE4D 2680/4885HPGD 125/4885
US-20230340331-A1 MONOAZO DICHROIC DYE COMPOUND, POLARIZING PLATE COMPOSITION COMPRISING SAME, POLARIZING PLATE FORMED THEREFROM, AND OPTICAL DEVICE COMPRISING SAME ORMDL3, WEE1, WEE2 OPRK1 3026/4885PDE4D 4458/4885HPGD 3574/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.