SCHEMBL544087

SCHEMBL544087

CN(CCCN)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ADRA2C P18825 1/20 0.49
CARM1 Q86X55 1/20 0.44
PRMT6 Q96LA8 1/20 0.44
PRMT8 Q9NR22 1/20 0.44
AOC3 Q16853 1/20 0.44
NOS1 P29475 1/20 0.43
NOS2 P35228 1/20 0.43
HRH3 Q9Y5N1 1/20 0.43
CA12 O43570 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41
PPARG P37231 1/20 0.41
TAAR1 Q96RJ0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8993948 0.94 MAOA (0.43) ADRA2CCARM1PRMT6PRMT8AOC3
SCHEMBL26782114 0.92 CHRM2 (0.46) ADRA2CCARM1PRMT6PRMT8AOC3
Iodide SCHEMBL10492775 0.92 ADRA2C (0.42) ADRA2CCARM1PRMT6PRMT8AOC3
SCHEMBL4395973 0.86 CARM1 (0.52) ADRA2CCARM1PRMT6PRMT8AOC3
SCHEMBL13645984 0.86 SIGMAR1 (0.48) AOC3CA12CA2CA9PPARG
SCHEMBL11145951 0.86 CA12 (0.47) AOC3CA12CA2CA9PPARG
Hydrochloric Acid SCHEMBL6890412 0.84 CARM1 (0.50) ADRA2CCARM1PRMT6PRMT8AOC3
SCHEMBL17037834 0.84 SIGMAR1 (0.52) AOC3CA12CA2CA9PPARG
SCHEMBL29059909 0.83 APP (0.53) AOC3CA12CA2CA9PPARG
SCHEMBL8643584 0.82 CHRM2 (0.46) CA12CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 317 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11814451-B2 Methods for preparing branched poly (2-hydroxyethyl methacrylate) at room temperature by inverse emulsion polymerization Changzhou University (CN) 2023-11-14 US claimed
US-20230018276-A1 METHODS FOR PREPARING BRANCHED POLY (2-HYDROXYETHYL METHACRYLATE) AT ROOM TEMPERATURE BY INVERSE EMULSION POLYMERIZATION Changzhou University (CN) 2023-01-19 US claimed
US-11377508-B2 Temperature-responsive poly(2-hydroxyethyl methacrylate) (PHEMA) and preparation method thereof Changzhou University (CN) 2022-07-05 US claimed
CN-111363083-B Method for preparing branched polyhydroxyethyl methacrylate at room temperature by inverse emulsion polymerization 常州大学 2022-02-11 CN claimed
CN-111393562-B Temperature-responsive polyhydroxyethyl methacrylate and preparation method thereof 常州大学 2021-04-30 CN claimed
CN-111393562-A Temperature response type polyhydroxyethyl methacrylate and preparation method thereof 常州大学 2020-07-10 CN claimed
CN-111363083-A Method for preparing branched polyhydroxyethyl methacrylate at room temperature by inverse emulsion polymerization 常州大学 2020-07-03 CN claimed
US-9737875-B2 Affinity reagents for protein purification IMPOSSIBLE FOODS INC. (US) 2017-08-22 US claimed
CN-104620104-B Affinity Reagents for Protein Purification 非凡食品有限公司 2017-03-01 CN claimed
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP claimed
WO-2006094633-A1 1- SULFONYL-PI PERDINE- 3 -CARBOXYL I C ACID AMIDE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE FOR THE TREATMENT OF TYPE II DIABETES MELLITUS F. HOFFMAN-LA ROCHE AG (CH) 2006-09-14 WO claimed
US-6967216-B2 Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor ASTRAZENECA AB (SE) 2005-11-22 US claimed
EP-1401841-B1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN GRUENENTHAL GMBH (DE) 2005-08-24 EP claimed
EP-1458711-A1 USE OF OXINDOLE DERIVATIVES IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 AstraZeneca AB (SE) 2004-09-22 EP claimed
US-20030225097-A1 Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by np y5 receptor ASTRAZENECA AB (SE) 2003-12-04 US claimed
WO-2003055877-A1 USE OF OXINDOLE DERIVATIVES IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER'S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 ASTRAZENECA AB (SE) 2003-07-10 WO claimed
EP-1278739-A1 AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR AstraZeneca AB (SE) 2003-01-29 EP claimed
US-20020058788-A1 Facile deprotection of Fmoc protected amino groups DISCOVERY PARTNERS INTERNATIONAL, INC. 2002-05-16 US claimed
WO-2001085714-A1 AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR ASTRAZENECA AB (SE) 2001-11-15 WO claimed
US-5710012-A DETECTION OF CHOLESTEROL BY RELEASE OF HYDROGEN PEROXIDE ACTIMED LABORATORIES, INC. (US) 1998-01-20 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020058788-A1 Facile deprotection of Fmoc protected amino groups DNPEP, LNPEP, NPEPPS ADRA2C 4324/4885CARM1 367/4885PRMT6 34/4885
US-20030225097-A1 Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by np y5 receptor NPY5R, NPY1R, NPY2R ADRA2C 200/4885CARM1 2670/4885PRMT6 913/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.