Sulisobenzone

Sulisobenzone

SCHEMBL545162

COc1cc(O)c(C(=O)c2ccccc2)cc1S(=O)(=O)O.O.O.O

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Sulisobenzone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 1/20 0.52
PDE4A known ✓ P27815 1/20 0.52
HRH1 known ✓ P35367 1/20 0.52
SLC6A3 known ✓ Q01959 1/20 0.52
PDE4D known ✓ Q08499 1/20 0.52
MEN1 known ✓ O00255 2/20 0.44
PTGS1 known ✓ P23219 1/20 0.42
PTGS2 known ✓ P35354 1/20 0.42
LMNA P02545 5/20 0.97
MAPT P10636 5/20 0.97
KMT2A Q03164 4/20 0.97
ALDH1A1 P00352 2/20 0.97
HPGD P15428 3/20 0.68
KDM4E B2RXH2 2/20 0.68
HSD17B10 Q99714 2/20 0.68
CYP3A4 P08684 1/20 0.68
RECQL P46063 1/20 0.68
MAPK1 P28482 2/20 0.52
HTT P42858 2/20 0.52
CYP1A2 P05177 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sulisobenzone SCHEMBL14058252 1.00 LMNA (0.97) LMNAMAPTKMT2AALDH1A1HPGD
Sulisobenzone SCHEMBL3932826 1.00 LMNA (0.97) LMNAMAPTKMT2AALDH1A1HPGD
Sulisobenzone SCHEMBL812671 0.99 MAPT (0.95) LMNAMAPTKMT2AALDH1A1HPGD
Sulisobenzone SCHEMBL167868 0.99 LMNA (1.00) LMNAMAPTKMT2AALDH1A1HPGD
Sulisobenzone SCHEMBL16330 0.99 LMNA (1.00) LMNAMAPTKMT2AALDH1A1HPGD
Sulisobenzone SCHEMBL9474717 0.99 LMNA (1.00) LMNAMAPTKMT2AALDH1A1HPGD
Sulisobenzone SCHEMBL29360128 0.99 LMNA (1.00) LMNAMAPTKMT2AALDH1A1HPGD
Sulisobenzone SCHEMBL6295950 0.97 LMNA (0.97) LMNAMAPTKMT2AALDH1A1HPGD
Sulisobenzone SCHEMBL22712408 0.97 LMNA (0.97) LMNAMAPTKMT2AALDH1A1HPGD
Sulisobenzone SCHEMBL10723301 0.97 LMNA (0.97) LMNAMAPTKMT2AALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 524 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107189197-B Comprehensive conveying pipe for high-strength insulating flame-retardant pipeline gallery 上海中塑管业有限公司 2020-05-12 CN claimed
US-4482204-A Ultraviolet absorbers in optical fiber coatings AT&T BELL LABORATORIES (US) 1984-11-13 US claimed
US-4087406-A Metal salts of hindered piperidine carboxylic acids and stabilized compositions CIBA-GEIGY CORPORATION (US) 1978-05-02 US claimed
WO-2026100525-A1 BLACK RESIN PARTICLE DISPERSION AND AQUEOUS INK COMPOSITION FOR WRITING IMPLEMENTS CONTAINING SAME 三菱鉛筆株式会社 2026-05-15 WO disclosed
EP-4692260-A1 KIT FOR THREE-COMPONENT COATING COMPOSITION, THREE-COMPONENT COATING COMPOSITION, AND IN-MOLD COATING METHOD Kansai Paint Co., Ltd (JP) 2026-02-11 EP disclosed
US-20260021615-A1 COATING COMPOSITION AND IN-MOLD COATING METHOD KANSAI PAINT CO LTD (JP) 2026-01-22 US disclosed
US-12485593-B2 Method for forming in-mold coating multi-layer coating film KANSAI PAINT CO., LTD. (JP) 2025-12-02 US disclosed
US-20250291269-A1 ELECTROSTATIC IMAGE DEVELOPING TONER, ELECTROSTATIC IMAGE DEVELOPER, TONER CARTRIDGE, PROCESS CARTRIDGE, IMAGE FORMING APPARATUS, AND IMAGE FORMING METHOD FUJIFILM BUSINESS INNOVATION CORP. (JP) 2025-09-18 US disclosed
US-20250230338-A1 THERMOSETTING COATING MATERIAL COMPOSITION, COATED ARTICLE, AND IN-MOLD COATING METHOD KANSAI PAINT CO., LTD. (JP) 2025-07-17 US disclosed
US-12325805-B2 Coating composition and in-mold coating method KANSAI PAINT CO., LTD. (JP) 2025-06-10 US disclosed
US-20250144859-A1 METHOD FOR FORMING IN-MOLD COATING MULTI-LAYER COATING FILM KANSAI PAINT CO., LTD. (JP) 2025-05-08 US disclosed
US-4017325-A Pigment composition HULL-SMITH CHEMICALS, INC. (US) 1977-04-12 US disclosed
US-4001181-A ACTINIC RADIATION STABILIZERS CIBA-GEIGY CORPORATION (US) 1977-01-04 US disclosed
US-3991012-A AGAINST ULTRAVIOLET DETERIORATION OF POLYMERS CIBA-GEIGY CORPORATION (US) 1976-11-09 US disclosed
US-3979360-A Compositions stabilized with benzoyloxybenzamides CIBA-GEIGY CORPORATION (US) 1976-09-07 US disclosed
US-3960809-A POLYMERS CIBA-GEIGY CORPORATION (US) 1976-06-01 US disclosed
US-3956361-A THERMAL AND OXIDATIVE STABILIZER FOR POLYMER CIBA-GEIGY CORPORATION (US) 1976-05-11 US disclosed
US-3941746-A Containing hindered phenolic norbornane-2,3-dicarboximides stabilized compositions CIBA-GEIGY CORPORATION (US) 1976-03-02 US disclosed
US-3939163-A Metal salts of hindered piperidine carboxylic acids and stabilized compositions CIBA-GEIGY CORPORATION (US) 1976-02-17 US disclosed
US-3931442-A Temporary modification of a pattern mask for use in forming a color CRT screen and a process for modifying the same GTE SYLVANIA INCORPORATED (US) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260021615-A1 COATING COMPOSITION AND IN-MOLD COATING METHOD VIM, VCL, C9 SLC6A2 4183/4885PDE4A 4305/4885HRH1 519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.