Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REV1 | Q9UBZ9 | 3/20 | 0.76 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.70 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.70 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.70 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453347 | 0.98 | REV1 (0.76) | REV1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL3916303 | 0.95 | REV1 (0.79) | REV1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL5451305 | 0.85 | MAPT (0.70) | REV1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL5455799 | 0.85 | FLT3 (0.68) | REV1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL5451446 | 0.85 | AIP (0.71) | REV1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL3916246 | 0.85 | MAPT (0.78) | REV1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL5448366 | 0.84 | ALDH1A1 (0.76) | REV1MAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL3128067 | 0.83 | FLT3 (0.92) | MAPTFLT3ALDH1A1RAB9APOLB | |
| SCHEMBL8290403 | 0.83 | FLT3 (0.87) | MAPTFLT3ALDH1A1NPC1RAB9A | |
| SCHEMBL10143922 | 0.82 | MAPT (1.00) | REV1MAPTDUSP3PTPN5PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275962-A1 | Heterobicyclic Compounds as Pharmaceutically Active Agents | GPC BIOTECH AG (DE) | 2007-11-29 | — | — | US | claimed |
| EP-1670804-A2 | HETEROBICYCLIC COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | GPC Biotech AG (DE) | 2006-06-21 | — | — | EP | claimed |
| WO-2005023818-A2 | HETEROBICYCLIC COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | GPC BIOTECH AG (DE) | 2005-03-17 | — | — | WO | claimed |
| US-20070275962-A1 | Heterobicyclic Compounds as Pharmaceutically Active Agents | GPC BIOTECH AG (DE) | 2007-11-29 | — | — | US | disclosed |
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275962-A1 | Heterobicyclic Compounds as Pharmaceutically Active Agents | TBCA, PARK7, NFATC1 | REV1 1861/4885MAPT 21/4885DUSP3 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.