SCHEMBL5454054

SCHEMBL5454054

OCCNC1CCCc2c1[nH]c1ccc(-c3ccccc3)cc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CDC42 P60953 1/20 1.00
GAA P10253 1/20 0.69
CASP6 P55212 1/20 0.69
PRMT5 O14744 2/20 0.53
CYP2D6 P10635 2/20 0.52
BRD3 Q15059 7/20 0.49
KCNH2 Q12809 1/20 0.47
RB1 P06400 4/20 0.46
MAPT P10636 2/20 0.46
ALOX15 P16050 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
MAPK1 P28482 1/20 0.46
MEN1 O00255 1/20 0.45
GLA P06280 1/20 0.45
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20180909 1.00 CDC42 (1.00) CDC42GAACASP6PRMT5CYP2D6
SCHEMBL12922440 0.90 CDC42 (0.82) CDC42GAACASP6PRMT5CYP2D6
SCHEMBL5449921 0.89 CDC42 (0.80) CDC42GAACASP6PRMT5CYP2D6
SCHEMBL24863190 0.87 CDC42 (0.77) CDC42GAACASP6PRMT5CYP2D6
SCHEMBL15167010 0.87 CDC42 (0.77) CDC42GAACASP6PRMT5CYP2D6
SCHEMBL5461141 0.87 CDC42 (0.76) CDC42GAACASP6PRMT5CYP2D6
SCHEMBL22135739 0.86 CDC42 (0.76) CDC42GAACASP6PRMT5CYP2D6
SCHEMBL5461734 0.86 CDC42 (0.76) CDC42GAACASP6PRMT5CYP2D6
SCHEMBL31721161 0.85 CDC42 (0.74) CDC42GAACASP6PRMT5CYP2D6
SCHEMBL31721117 0.85 CDC42 (0.74) CDC42GAACASP6PRMT5CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 173 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12569494-B2 Compositions and methods to promote thymic regeneration FRED HUTCHINSON CANCER CENTER (US) 2026-03-10 US claimed
US-20260041687-A1 METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA PENN STATE RES FOUND (US) 2026-02-12 US claimed
EP-3999053-B1 METHOD OF TREATING NEOPLASTIC DISEASES WITH A CDC42-SPECIFIC INHIBITOR CHILDRENS HOSPITAL MED CT (US) 2026-01-21 EP claimed
US-12472185-B2 Methods for killing antibiotic tolerant bacteria THE PENN STATE RESEARCH FOUNDATION (US) 2025-11-18 US claimed
WO-2025127812-A1 METHOD FOR PREPARING ENDOMETRIAL ORGANOID AND USES THEREOF FOR TREATING UTERINE FIBROSIS AND AMELIORATING AGING 차의과학대학교 산학협력단 2025-06-19 WO claimed
US-20250144291-A1 ARTIFICIAL INTELLIGENCE BASED IMPLANTABLE DRUG DELIVERY SYSTEM Manta Implant LLC (US) 2025-05-08 US claimed
CN-119846752-A Reflective annular color wheel for laser display 江苏锡沂高新材料产业技术研究院有限公司 2025-04-18 CN claimed
CN-119161104-A Multicolor fluorescent glass ceramic, preparation method thereof, LED light-emitting device and LD light-emitting device 宁波大学 2024-12-20 CN claimed
EP-4461315-A2 CDC-42 INHIBITORS FOR USE IN THE TREATMENT OF AGE-RELATED DEPRESSION, SARCOPENIA OR FRAILTY Children's Hospital Medical Center (US) 2024-11-13 EP claimed
EP-4013402-B1 CDC-42 INHIBITORS FOR USE IN THE TREATMENT OF AGE-RELATED DEPRESSION, SARCOPENIA OR FRAILTY CHILDRENS HOSPITAL MED CT (US) 2024-11-06 EP claimed
US-20230263800-A1 COMPOSITIONS AND METHODS TO PROMOTE THYMIC FUNCTION FRED HUTCHINSON CANCER CENTER (US) 2023-08-24 US claimed
US-20230201206-A1 METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA THE PENN STATE RESEARCH FOUNDATION 2023-06-29 US claimed
US-11654146-B2 Methods for killing antibiotic tolerant bacteria THE PENN STATE RESEARCH FOUNDATION (US) 2023-05-23 US claimed
CN-112971485-B Antiviral cow leather mat and preparation method thereof 上海水星家用纺织品股份有限公司 2023-03-10 CN claimed
US-20220288020-A1 METHOD OF TREATING NEOPLASTIC DISEASES WITH A CDC42-SPECIFIC INHIBITOR CHILDRENS HOSPITAL MED CT (US) 2022-09-15 US claimed
US-20220288197-A1 METHODS OF TREATING A SUBJECT WITH A CDC42-SPECIFIC INHIBITOR CHILDREN'S HOSPITAL MEDICAL CENTER 2022-09-15 US claimed
EP-4013402-A1 METHODS OF TREATING A SUBJECT WITH A CDC42-SPECIFIC INHIBITOR Children's Hospital Medical Center (US) 2022-06-22 EP claimed
EP-3999053-A1 METHOD OF TREATING NEOPLASTIC DISEASES WITH A CDC42-SPECIFIC INHIBITOR Children's Hospital Medical Center (US) 2022-05-25 EP claimed
WO-2022098776-A1 COMPOSITIONS AND METHODS TO PROMOTE THYMIC FUNCTION FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2022-05-12 WO claimed
EP-3964206-A1 COMPOUNDS FOR THE TREATMENT OF COVID-19 Dompe' Farmaceutici S.P.A. (IT) 2022-03-09 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220288020-A1 METHOD OF TREATING NEOPLASTIC DISEASES WITH A CDC42-SPECIFIC INHIBITOR CDC42, RAC1, TNK2 CDC42 1/4885GAA 886/4885CASP6 2882/4885
US-12569494-B2 Compositions and methods to promote thymic regeneration CDC42, BMP4, TPMT CDC42 1/4885GAA 4352/4885CASP6 242/4885
US-20230263800-A1 COMPOSITIONS AND METHODS TO PROMOTE THYMIC FUNCTION BMP4, P2RY2, GPR39 CDC42 323/4885GAA 4219/4885CASP6 3817/4885
US-20260041687-A1 METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA VDAC1, VDAC3, VIL1 CDC42 1730/4885GAA 4155/4885CASP6 813/4885
US-11654146-B2 Methods for killing antibiotic tolerant bacteria CLPP, SPOUT1, CASP3 CDC42 1823/4885GAA 523/4885CASP6 33/4885
US-12472185-B2 Methods for killing antibiotic tolerant bacteria CLPP, SPOUT1, CASP3 CDC42 1823/4885GAA 523/4885CASP6 33/4885
US-20220288197-A1 METHODS OF TREATING A SUBJECT WITH A CDC42-SPECIFIC INHIBITOR CDC42, TNK2, RAC1 CDC42 1/4885GAA 1393/4885CASP6 288/4885
US-20230201206-A1 METHODS FOR KILLING ANTIBIOTIC TOLERANT BACTERIA CLPP, SPOUT1, CASP3 CDC42 1823/4885GAA 523/4885CASP6 33/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.