Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 11/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5279447 | 0.76 | MAOA (0.48) | MAOAALDH1A1KDM4ELMNANPC1 | |
| SCHEMBL7236286 | 0.71 | MAOA (0.68) | MAOAALDH1A1KDM4ELMNANPC1 | |
| SCHEMBL20346660 | 0.69 | MAOA (0.62) | MAOAALDH1A1KDM4ELMNANPC1 | |
| SCHEMBL10127076 | 0.68 | MAOA (0.59) | MAOAALDH1A1KDM4ELMNANPC1 | |
| SCHEMBL30346412 | 0.67 | MAOA (0.79) | MAOAALDH1A1KDM4ELMNANPC1 | |
| SCHEMBL14443979 | 0.67 | NUDT1 (0.53) | MAOAALDH1A1KDM4ELMNANPC1 | |
| SCHEMBL14443973 | 0.67 | IKBKB (0.58) | MAOAKDM4ECYP3A4 | |
| SCHEMBL18240048 | 0.67 | MAOA (0.67) | MAOAALDH1A1KDM4ELMNANPC1 | |
| SCHEMBL20346583 | 0.66 | MAOA (0.67) | MAOAALDH1A1KDM4ELMNANPC1 | |
| SCHEMBL27714097 | 0.66 | MAOA (0.70) | MAOAALDH1A1KDM4ELMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244760-B2 | Methods for preparation and use of psorospermin analogs | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-07-17 | — | — | US | disclosed |
| US-20060084698-A1 | Methods for preparation and use of psorospermin analogs | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2006-04-20 | — | — | US | disclosed |
| EP-1395596-A2 | METHODS FOR PREPARATION AND USE OF PSOROSPERMIN ANALOGS | Board of Regents, The University of Texas System (US) | 2004-03-10 | — | — | EP | disclosed |
| US-20030120093-A1 | Methods for preparation and use of psorospermin analogs | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2003-06-26 | — | — | US | disclosed |
| WO-2002094836-A2 | METHODS FOR PREPARATION AND USE OF PSOROSPERMIN ANALOGS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030120093-A1 | Methods for preparation and use of psorospermin analogs | DHODH, DHFR, DHPS | MAOA 894/4885ALDH1A1 2211/4885KDM4E 3811/4885 |
| US-20060084698-A1 | Methods for preparation and use of psorospermin analogs | DHPS, DHFR, DHODH | MAOA 778/4885ALDH1A1 2358/4885KDM4E 4062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.