Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | PRKACG | P22612 | 1/20 | 0.56 |
| ▸ | PRKACB | P22694 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 12/20 | 0.52 |
| ▸ | IDH1 | O75874 | 1/20 | 0.52 |
| ▸ | PRKCB | P05771 | 5/20 | 0.49 |
| ▸ | PRKCA | P17252 | 5/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5326609 | 0.90 | PRKACA (0.69) | CDK4PRKACAPRKACGPRKACBCCND1 | |
| SCHEMBL9087225 | 0.84 | PRKACA (0.80) | CDK4PRKACAPRKACGPRKACBCCND1 | |
| SCHEMBL4340705 | 0.80 | GSK3B (0.71) | CDK4PRKACAPRKACGPRKACBCCND1 | |
| SCHEMBL8245376 | 0.80 | CAMK2D (0.69) | PRKACAPRKACGPRKACB | |
| SCHEMBL9086399 | 0.79 | PRKACA (0.68) | CDK4PRKACAPRKACGPRKACBCCND1 | |
| SCHEMBL26296991 | 0.78 | GSK3B (0.60) | CDK4PRKACAPRKACGPRKACBCCND1 | |
| SCHEMBL8239373 | 0.77 | PRKACA (0.71) | CDK4PRKACAPRKACGPRKACBCCND1 | |
| SCHEMBL5755241 | 0.77 | PRKCA (0.71) | CDK4PRKACAPRKACGPRKACBCCND1 | |
| SCHEMBL9088042 | 0.77 | PRKACA (0.80) | CDK4PRKACAPRKACGPRKACBCCND1 | |
| SCHEMBL7873644 | 0.76 | PRKACA (0.80) | CDK4PRKACAPRKACGPRKACBCCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008514-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | GEORGETOWN UNIVERSITY (US) | 2007-01-18 | — | — | WO | disclosed |