Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.48 |
| ▸ | NOS2 | P35228 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 8/20 | 0.38 |
| ▸ | MAOA | P21397 | 7/20 | 0.38 |
| ▸ | KDM1A | O60341 | 5/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3115176 | 1.00 | NOS1 (0.48) | NOS1NOS2TAAR1MAOBMAOA | |
| SCHEMBL4751341 | 1.00 | NOS1 (0.48) | NOS1NOS2TAAR1MAOBMAOA | |
| SCHEMBL186274 | 0.93 | NOS1 (0.52) | NOS1NOS2TAAR1MAOBMAOA | |
| SCHEMBL3173918 | 0.91 | NOS1 (0.50) | NOS1NOS2TAAR1MAOBMAOA | |
| SCHEMBL8542775 | 0.91 | NOS1 (0.50) | NOS1NOS2TAAR1MAOBMAOA | |
| SCHEMBL1749974 | 0.83 | NOS1 (0.44) | NOS1NOS2TAAR1MAOBMAOA | |
| SCHEMBL7765323 | 0.83 | ALDH1A1 (0.41) | NOS1NOS2MAOBMAOACYP2D6 | |
| SCHEMBL7764535 | 0.83 | ALDH1A1 (0.41) | NOS1NOS2MAOBMAOACYP2D6 | |
| SCHEMBL7854036 | 0.81 | NOS1 (0.38) | NOS1NOS2TAAR1MAOBMAOA | |
| SCHEMBL2749914 | 0.80 | CYP1A2 (0.39) | NOS1NOS2CYP2C19CYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 412 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240218022-A1 | ANTI-VISTA MACROCYCLIC PEPTIDES AND COMPOSITIONS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-07-04 | — | — | US | claimed |
| CN-114105887-B | Aminopyrimidine derivative and preparation method and application thereof | 沈阳药科大学 | 2023-12-01 | — | — | CN | claimed |
| WO-2023040537-A1 | AMINOPYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 沈阳药科大学 | 2023-03-23 | — | — | WO | claimed |
| CN-114105887-A | Aminopyrimidine derivative and preparation method and application thereof | 沈阳药科大学 | 2022-03-01 | — | — | CN | claimed |
| EP-3898639-A1 | OXOPYRIDO[1,2-A]PYRIMIDINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | F. Hoffmann-La Roche AG (CH) | 2021-10-27 | — | — | EP | claimed |
| US-20210317141-A1 | OXOPYRIDO[1,2-A]PYRIMIDINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2021-10-14 | — | — | US | claimed |
| CN-113195503-A | Oxopyrido [1,2-A ] pyrimidine compounds for the treatment and prevention of bacterial infections | 豪夫迈·罗氏有限公司 | 2021-07-30 | — | — | CN | claimed |
| WO-2020127624-A1 | OXOPYRIDO[1,2-A]PYRIMIDINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-25 | — | — | WO | claimed |
| EP-2872511-B1 | IMIDAZOPYRAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB BIOPHARMA SPRL (BE) | 2019-01-16 | — | — | EP | claimed |
| EP-2872508-B1 | IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | UCB BIOPHARMA SPRL (BE) | 2018-08-29 | — | — | EP | claimed |
| EP-1453789-A2 | N,N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2004-09-08 | — | — | EP | claimed |
| US-20030186978-A1 | Novel telomerase inhibitors | PHARMACIA ITALIA, SPA (IT) | 2003-10-02 | — | — | US | claimed |
| WO-2003040096-A2 | N, N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-15 | — | — | WO | claimed |
| JP-2002500641-A | — | — | 2002-01-08 | — | — | JP | claimed |
| WO-2001096339-A1 | NOVEL TELOMERASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-20 | — | — | WO | claimed |
| EP-0998451-A1 | SUBSTITUTED 3,3-DIAMINO-2-PROPENENITRILES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-05-10 | — | — | EP | claimed |
| WO-1998050344-A1 | SUBSTITUTED 3,3-DIAMINO-2-PROPENENITRILES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-11-12 | — | — | WO | claimed |
| EP-0705259-B1 | PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-02-25 | — | — | EP | claimed |
| EP-0705259-A1 | PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-10 | — | — | EP | claimed |
| WO-1995000508-A1 | PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-01-05 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317141-A1 | OXOPYRIDO[1,2-A]PYRIMIDINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | TYMS, UMPS, DPYD | NOS1 1140/4885NOS2 2743/4885TAAR1 1567/4885 |
| US-20240218022-A1 | ANTI-VISTA MACROCYCLIC PEPTIDES AND COMPOSITIONS | VIP, SGTA, NGLY1 | NOS1 2672/4885NOS2 3431/4885TAAR1 3108/4885 |
| US-20030186978-A1 | Novel telomerase inhibitors | TERT, TERF2IP, TERF2 | NOS1 3551/4885NOS2 4040/4885TAAR1 3797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.