Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1425254 | 0.84 | OPRM1 (0.49) | L3MBTL1OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL1945523 | 0.83 | OPRM1 (0.59) | L3MBTL1OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL5467320 | 0.78 | SMN1; SMN2 (0.55) | L3MBTL1OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL5466581 | 0.74 | L3MBTL1 (0.56) | L3MBTL1NOS3NOS1NOS2SMN1; SMN2 | |
| SCHEMBL3023811 | 0.73 | L3MBTL1 (0.52) | L3MBTL1NOS3NOS1NOS2SMN1; SMN2 | |
| SCHEMBL9312413 | 0.73 | L3MBTL1 (0.65) | L3MBTL1SMN1; SMN2HSD17B10APPMAPT | |
| SCHEMBL6796331 | 0.72 | MAPT (0.59) | L3MBTL1OPRM1APPMAPTPOLB | |
| SCHEMBL5468994 | 0.72 | L3MBTL1 (0.53) | L3MBTL1NOS3NOS1NOS2APP | |
| SCHEMBL6611054 | 0.72 | NOS2 (0.51) | L3MBTL1OPRD1OPRK1NOS2SMN1; SMN2 | |
| SCHEMBL9529108 | 0.71 | APP (0.59) | L3MBTL1OPRM1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185168-A1 | Piperidine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-08-09 | — | — | US | disclosed |
| EP-1736474-A1 | PIPERIDINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185168-A1 | Piperidine derivatives | GRIN2C, GRIN1, GRIN3A | L3MBTL1 2896/4885OPRM1 54/4885OPRL1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.