Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Trifluoroacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 5/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 7/20 | 0.32 |
| ▸ | ACLY | P53396 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL72727 | 0.96 | — | — | |
| Trifluoroacetic Acid SCHEMBL28583554 | 0.96 | ALDH1A1 (0.40) | ALDH1A1TSHRL3MBTL1THRBTP53 | |
| Trifluoroacetic Acid SCHEMBL28159900 | 0.92 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1THRBTP53 | |
| Trifluoroacetic Acid SCHEMBL28010805 | 0.92 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1THRBTP53 | |
| Trifluoroacetic Acid SCHEMBL11213859 | 0.92 | ALDH1A1 (0.42) | ALDH1A1TSHRL3MBTL1THRBTP53 | |
| Trifluoroacetic Acid SCHEMBL4651002 | 0.92 | ALDH1A1 (0.42) | ALDH1A1TSHRL3MBTL1THRBTP53 | |
| Trifluoroacetic Acid SCHEMBL96736 | 0.92 | — | — | |
| Trifluoroacetic Acid SCHEMBL21802705 | 0.92 | ALDH1A1 (0.42) | ALDH1A1TSHRL3MBTL1THRBTP53 | |
| Trifluoroacetic Acid SCHEMBL8820428 | 0.92 | ALDH1A1 (0.42) | ALDH1A1TSHRL3MBTL1THRBTP53 | |
| Trifluoroacetic Acid SCHEMBL4962364 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 300 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118330070-A | Ultra-high performance liquid chromatography determination method for related substances of atorvastatin maleate | 瑞阳制药股份有限公司 | 2024-07-12 | — | — | CN | claimed |
| CN-117665144-A | Method for measuring content of sodium stearyl fumarate in pharmaceutical composition | 北京吉洛华制药有限公司 | 2024-03-08 | — | — | CN | claimed |
| CN-117305127-A | Penicillium sclerotium HY5 and application thereof, azone compound, preparation method and application thereof, and pharmaceutical composition | 贵州省烟草公司遵义市公司 | 2023-12-29 | — | — | CN | claimed |
| EP-3406591-B1 | DICAFFEOYL-SPERMIDINE DERIVATIVE GLYCOSIDE AND USE THEREOF | UNIV JINAN (CN) | 2023-09-06 | — | — | EP | claimed |
| CN-116242938-A | Determination method of sodium stearyl fumarate impurity | 北京吉洛华制药有限公司 | 2023-06-09 | — | — | CN | claimed |
| CN-111272916-B | Method for detecting content of penicillin V acid | 河北华北制药华恒药业有限公司 | 2023-03-21 | — | — | CN | claimed |
| CN-112014510-B | Detection method for determining chloroacetic acid residue in cinepazide maleate intermediate by HPLC (high performance liquid chromatography) method | 瀚盟测试科技（天津）有限公司 | 2022-07-05 | — | — | CN | claimed |
| CN-114689739-A | 99mSeparation method of Tc-TRODAT-1 diastereoisomer | 江苏省原子医学研究所 | 2022-07-01 | — | — | CN | claimed |
| CN-113759049-B | Method for detecting ezetimibe rosuvastatin calcium tablet related substances | 南京科默生物医药有限公司 | 2022-02-15 | — | — | CN | claimed |
| CN-113759049-A | Method for detecting ezetimibe rosuvastatin calcium tablet related substances | 南京科默生物医药有限公司 | 2021-12-07 | — | — | CN | claimed |
| CN-107840867-A | A kind of 23 aldehyde asiatic acid, preparation method and the application in stem cell field | 南京盖斯夫医药科技有限公司 | 2018-03-27 | — | — | CN | claimed |
| CN-107652351-A | A kind of 2 ketone asiatic acid, preparation method and the application in stem cell field | 南京盖斯夫医药科技有限公司 | 2018-02-02 | — | — | CN | claimed |
| CN-107586313-A | A kind of 3 ketone asiatic acid, preparation method and the application in stem cell field | 南京盖斯夫医药科技有限公司 | 2018-01-16 | — | — | CN | claimed |
| CN-104749288-B | A kind of liquid phase chromatography analytical method of Parecoxib Sodium about material | 上海秀新臣邦医药科技有限公司 | 2017-03-29 | — | — | CN | claimed |
| CN-105646619-A | Dicaffeoyl-spermidine cyclization derivative and application thereof | 暨南大学 | 2016-06-08 | — | — | CN | claimed |
| CN-105646611-A | Dicaffeoyl-spermidine cyclization derivative glycoside and application thereof | 暨南大学 | 2016-06-08 | — | — | CN | claimed |
| CN-105012805-A | Preparation and detection method of hepatitis B detoxicating capsule | SHNAGHAI HAIHONG INDUSTRY GROUP CHAOHU C DRAGON PHARMACY CO LTD | 2015-11-04 | — | — | CN | claimed |
| CN-104749288-A | Liquid chromatographic analysis method for parecoxib-sodium related substances | SHANGHAI XIUXIN CHENPON PHARMACEUTICAL TECHNOLOGY CO LTD | 2015-07-01 | — | — | CN | claimed |
| CN-101857590-A | Chromone ketoside compounds and purification method and application thereof | INST MATERIA MEDICA CAMS | 2010-10-13 | — | — | CN | claimed |
| CN-101694487-A | Screening method, extracting method, content measuring method and application of glycyrrhisoflavone in liquorice | NINGXIA HUI AUTONOMOUS PREFECT | 2010-04-14 | — | — | CN | claimed |