Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5480473 | 1.00 | TSHR (0.53) | TSHRSOS2ADRB3ADRB1ADRB2 | |
| SCHEMBL5859950 | 0.89 | TSHR (0.51) | TSHRSOS2ADRB3ADRB1ADRB2 | |
| SCHEMBL5857882 | 0.89 | TSHR (0.51) | TSHRSOS2ADRB3ADRB1ADRB2 | |
| SCHEMBL5485060 | 0.85 | ADRB3 (0.54) | TSHRADRB3ADRB1ADRB2BCHE | |
| SCHEMBL5479233 | 0.85 | ADRB3 (0.54) | TSHRADRB3ADRB1ADRB2BCHE | |
| SCHEMBL14527122 | 0.85 | SOS2 (0.58) | SOS2ADRB3ADRB1ADRB2HTR1A | |
| SCHEMBL7604319 | 0.83 | TSHR (0.52) | TSHRADRB3ADRB1ADRB2HTR2A | |
| SCHEMBL7867296 | 0.83 | SOS2 (0.65) | SOS2ADRB3ADRB1HTR1AADRA2A | |
| SCHEMBL5479349 | 0.83 | SOS2 (0.55) | SOS2ADRB1HTR1AADRA2ASLC6A2 | |
| SCHEMBL7859267 | 0.83 | ADRB3 (0.60) | SOS2ADRB3ADRB1ADRB2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217724-B2 | Indole, indazole, and benzazole derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-05-15 | — | — | US | disclosed |
| US-7115412-B2 | Process for the preparation of optically active 7-substituted-3-(2-aminopropyl)indole derivatives and intermediates therefor | MERCIAN CORPORATION (JP) | 2006-10-03 | — | — | US | disclosed |
| US-20060063762-A1 | Indole indazole and benzazole derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2006-03-23 | — | — | US | disclosed |
| EP-1514869-A1 | INDOLE, INDAZOLE, AND BENZAZOLE DERIVATIVE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-03-16 | — | — | EP | disclosed |
| US-20030181732-A1 | Producing a tryptophan in the presence of a tryptophan-synthesizing enzyme originating in microorganisms, forming adrenergic receptors | MERCIAN CORPORATION (JP) | 2003-09-25 | — | — | US | disclosed |
| EP-1275730-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE 7-SUBSTITUTED-3-(2-AMINOPROPYL)INDOLE DERIVATIVES AND INTERMEDIATES FOR PRODUCING THE SAME | MERCIAN CORPORATION (JP) | 2003-01-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063762-A1 | Indole indazole and benzazole derivative | ADRB3, ADRA2C, ADRB2 | TSHR 174/4885SOS2 4375/4885ADRB3 1/4885 |
| US-20030181732-A1 | Producing a tryptophan in the presence of a tryptophan-synthesizing enzyme originating in microorganisms, forming adrenergic receptors | TPH1, TPH2, SRR | TSHR 538/4885SOS2 959/4885ADRB3 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.