SCHEMBL5482086

SCHEMBL5482086

CC(C)N(C(C)C)P(OCCC#N)OC[C@H]1O[C@@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)C[C@@H]1NC(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
P2RY12 Q9H244 9/20 0.37
PRMT6 Q96LA8 1/20 0.36
P2RY2 P41231 1/20 0.36
P2RY1 P47900 1/20 0.36
P2RY6 Q15077 1/20 0.36
DNPH1 O43598 2/20 0.35
DOT1L Q8TEK3 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17231772 1.00 P2RY12 (0.37) P2RY12PRMT6P2RY2P2RY1P2RY6
SCHEMBL26050307 0.91 PRMT6 (0.40) P2RY12PRMT6P2RY2P2RY1P2RY6
SCHEMBL19519374 0.91 P2RY12 (0.37) P2RY12PRMT6P2RY2P2RY1P2RY6
SCHEMBL23547992 0.89 PRMT6 (0.40) P2RY12PRMT6P2RY2P2RY1P2RY6
SCHEMBL26050516 0.87 P2RY12 (0.32) P2RY12PRMT6P2RY2P2RY1P2RY6
SCHEMBL26050510 0.87 P2RY12 (0.32) P2RY12PRMT6P2RY2P2RY1P2RY6
SCHEMBL17283015 0.87 P2RY12 (0.32) P2RY12PRMT6P2RY2P2RY1P2RY6
SCHEMBL7206380 0.86 PRMT6 (0.35) P2RY12PRMT6
SCHEMBL5482091 0.85 P2RY12 (0.37) P2RY12PRMT6P2RY2P2RY1P2RY6
SCHEMBL7522626 0.85 PRMT6 (0.34) P2RY12PRMT6P2RY2P2RY1P2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4286519-A2 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF MAKING THE SAME GERON CORPORATION (US) 2023-12-06 EP disclosed
EP-3137479-B1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF MAKING THE SAME GERON CORP (US) 2023-08-30 EP disclosed
US-10392418-B2 Oligonucleotide compositions and methods of making the same GERON CORPORATION (US) 2019-08-27 US disclosed
US-20180016293-A1 Oligonucleotide Compositions and Methods of Making the Same BIOPHARMA CREDIT PLC [COLLATERAL AGENT] (GB) 2018-01-18 US disclosed
US-20180016294-A1 Oligonucleotide Compositions and Methods of Making the Same BIOPHARMA CREDIT PLC [COLLATERAL AGENT] (GB) 2018-01-18 US disclosed
US-9796747-B2 Oligonucleotide compositions and methods of making the same GERON CORPORATION (US) 2017-10-24 US disclosed
US-20150337314-A1 Oligonucleotide Compositions and Methods of Making the Same BIOPHARMA CREDIT PLC [COLLATERAL AGENT] (GB) 2015-11-26 US disclosed
US-20070117773-A1 Telomerase-inhibiting ENA oligonucleotide SANKYO COMPANY, LIMITED (JP) 2007-05-24 US disclosed
EP-1783216-A1 TELOMERASE-INHIBITORY ENA OLIGONUCLEOTIDE Sankyo Company, Limited (JP) 2007-05-09 EP disclosed
EP-0882059-A1 SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDE N3-'P5'- PHOSPHORAMIDATES LYNX THERAPEUTICS, INC. (US) 1998-12-09 EP disclosed
WO-1997031009-A1 SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDE N3'→P5' PHOSPHORAMIDATES LYNX THERAPEUTICS, INC. (US) 1997-08-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150337314-A1 Oligonucleotide Compositions and Methods of Making the Same RNGTT, NSUN2, POLN P2RY12 1532/4885PRMT6 3127/4885P2RY2 1700/4885
US-10392418-B2 Oligonucleotide compositions and methods of making the same RNGTT, NSUN2, POLN P2RY12 1532/4885PRMT6 3127/4885P2RY2 1700/4885
US-20070117773-A1 Telomerase-inhibiting ENA oligonucleotide TERT, ENO1, TERB1 P2RY12 1500/4885PRMT6 2148/4885P2RY2 2572/4885
US-20180016293-A1 Oligonucleotide Compositions and Methods of Making the Same RNGTT, NSUN2, POLN P2RY12 1532/4885PRMT6 3127/4885P2RY2 1700/4885
US-20180016294-A1 Oligonucleotide Compositions and Methods of Making the Same RNGTT, NSUN2, POLN P2RY12 1532/4885PRMT6 3127/4885P2RY2 1700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.