Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377130 | 0.86 | — | — | |
| SCHEMBL7639404 | 0.86 | TSHR (0.30) | — | |
| SCHEMBL8309815 | 0.86 | ALDH1A1 (0.31) | — | |
| SCHEMBL10500370 | 0.86 | — | — | |
| SCHEMBL11253293 | 0.86 | TSHR (0.30) | — | |
| SCHEMBL10684443 | 0.86 | — | — | |
| SCHEMBL11755774 | 0.86 | TSHR (0.30) | — | |
| SCHEMBL17476388 | 0.86 | — | — | |
| SCHEMBL17476390 | 0.86 | TSHR (0.30) | — | |
| Lithium Ion SCHEMBL6050085 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1533379-A | Small synthesis of pyridine-based pharmaceutical intermediates containing sulfur in the 2-and 3-positions | �Ϻ���ͨ��ѧ | 2004-09-29 | — | — | CN | claimed |
| US-20150133663-A1 | NOVEL SYNTHESIS METHOD | GE HEALTHCARE LIMITED (GB) | 2015-05-14 | — | — | US | disclosed |
| EP-2758390-A1 | NOVEL SYNTHESIS METHOD | GE Healthcare UK Limited (GB) | 2014-07-30 | — | — | EP | disclosed |
| US-20140140928-A1 | 5HT1A ANTAGONIST USEFUL FOR IN VIVO IMAGING | GE HEALTHCARE LIMITED (GB) | 2014-05-22 | — | — | US | disclosed |
| WO-2013041682-A1 | NOVEL SYNTHESIS METHOD | GE HEALTHCARE LIMITED (GB) | 2013-03-28 | — | — | WO | disclosed |
| EP-1392653-B1 | A SHORT SYNTHESIS OF PYRIDINE-BASED PHARMACEUTICAL INTERMEDIATES WITH SULFUR-CONTAINING GROUPS AT THE 2- AND 3-POSITIONS | UNIV NORTH CAROLINA STATE (US) | 2007-08-15 | — | — | EP | disclosed |
| US-6987189-B2 | Short synthesis of pyridine-based pharmaceutical intermediates | NORTH CAROLINA STATE UNIVERSITY (US) | 2006-01-17 | — | — | US | disclosed |
| US-20050065347-A1 | Short synthesis of pyridine-based pharmaceutical intermediates | COMINS DANIEL L (US) | 2005-03-24 | — | — | US | disclosed |
| US-6855825-B2 | Short synthesis of pyridine-based pharmaceutical intermediates | NORTH CAROLINA STATE UNIVERSITY (US) | 2005-02-15 | — | — | US | disclosed |
| CN-1533379-A | Small synthesis of pyridine-based pharmaceutical intermediates containing sulfur in the 2-and 3-positions | �Ϻ���ͨ��ѧ | 2004-09-29 | — | — | CN | disclosed |
| US-4867781-A | PRE- AND POSTEMERGENCE HERBICIDES; NONPHYTOTOXIC | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-09-19 | — | — | US | disclosed |
| US-4802911-A | HERBICIDES, PLANT GROWTH REGULATORS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-02-07 | — | — | US | disclosed |
| US-4783285-A | CATALYZED BY ACYCLIC OR CYCLIC POLYETHER | E. I. DUPONT DE NEMOURS AND COMPANY (US) | 1988-11-08 | — | — | US | disclosed |
| EP-0107979-B1 | NOVEL PHENYL-SUBSTITUTED SULFONAMIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-10-12 | — | — | EP | disclosed |
| US-4741761-A | HERBICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-05-03 | — | — | US | disclosed |
| US-4683091-A | Process for the nucleophilic substitution of unactivated aromatic and heteroaromatic substrates | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-07-28 | — | — | US | disclosed |
| US-4620870-A | HERBICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1986-11-04 | — | — | US | disclosed |
| US-4586950-A | HERBICIDES | E. I. DU PONT DE NEMOURS & COMPANY (US) | 1986-05-06 | — | — | US | disclosed |
| EP-0107979-A1 | Novel phenyl-substituted sulfonamides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-05-09 | — | — | EP | disclosed |
| EP-0094821-A1 | Process for the nucleophilic substitution of unactivated aromatic and heteroaromatic substrates | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-11-23 | — | — | EP | disclosed |