Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 3/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2991307 | 1.00 | LMNA (0.59) | LMNADNM1TSHRTHRBALDH1A1 | |
| SCHEMBL1944724 | 1.00 | LMNA (0.59) | LMNADNM1TSHRTHRBALDH1A1 | |
| SCHEMBL11821234 | 1.00 | LMNA (0.59) | LMNADNM1TSHRTHRBALDH1A1 | |
| SCHEMBL10582089 | 1.00 | LMNA (0.59) | LMNADNM1TSHRTHRBALDH1A1 | |
| SCHEMBL1697645 | 0.97 | LMNA (0.55) | LMNADNM1TSHRTHRBALDH1A1 | |
| SCHEMBL17822464 | 0.97 | LMNA (0.62) | LMNADNM1TSHRTHRBALDH1A1 | |
| SCHEMBL3634317 | 0.97 | LMNA (0.62) | LMNADNM1TSHRTHRBALDH1A1 | |
| SCHEMBL8026611 | 0.97 | LMNA (0.62) | LMNADNM1TSHRTHRBALDH1A1 | |
| SCHEMBL11330180 | 0.97 | LMNA (0.62) | LMNADNM1TSHRTHRBALDH1A1 | |
| SCHEMBL4949893 | 0.97 | LMNA (0.62) | LMNADNM1TSHRTHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270332-A1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | VALLEE BERT L | 2007-11-22 | — | — | US | disclosed |
| EP-1645272-A2 | Daidzin derivatives for the treatment of alcohol dependence or alcohol abuse | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6255497-B1 | DAIDZIN DERIVATIVES AS ENZYME INHIBITORS OF ALDEHYDE DEHYDROGENASE; USEFUL IN TREATING ALCOHOLISM | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. | 2001-07-03 | — | — | US | disclosed |
| EP-1077697-A1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| EP-0592583-B1 | METHOD FOR THE INHIBITION OF ALDH-I USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | ENDOWMENT FOR RES IN HUMAN BIO (US) | 2001-01-31 | — | — | EP | disclosed |
| US-6121010-A | SCREENING FOR COMPOUNDS WHICH REDUCE ALCOHOL (ETHANOL) CONSUMPTION BY DETERMINING EFFECTIVENESS FOR INHIBITING ALDEHYDE DEHYDROGENASE ACTIVITY ON ALDEHYDES DERIVED FROM SUBSTRATES OF MONOAMINE OXIDASE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY (US) | 2000-09-19 | — | — | US | disclosed |
| WO-1999058124-A1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 1999-11-18 | — | — | WO | disclosed |
| US-5886028-A | REDUCING ALCOHOL CONSUMPTION BY ADMINISTERING AN ENZYME INHIBITOR | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 1999-03-23 | — | — | US | disclosed |
| US-5624910-A | INHIBITING ALDEHYDE DEHYRDOGENASE ACTIVITY USING DAIDZIN | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0592583-A1 | METHOD FOR THE INHIBITION OF ALDH-I USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 1994-04-20 | — | — | EP | disclosed |
| WO-1993000896-A1 | METHOD FOR THE INHIBITION OF ALDH-I USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 1993-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270332-A1 | METHODS AND ASSAYS USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | ADH1A, ADH5, ADH1C | LMNA 3053/4885DNM1 1598/4885TSHR 2373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.