SCHEMBL5490469

SCHEMBL5490469

Nn1cnc2c(S)ncnc21

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 12/20 0.37
ADORA1 P30542 8/20 0.37
PI4KA P42356 10/20 0.34
PI4K2B Q8TCG2 10/20 0.34
PI4K2A Q9BTU6 10/20 0.34
PI4KB Q9UBF8 10/20 0.34
ADORA2B P29275 4/20 0.34
EGFR P00533 1/20 0.33
ADORA3 P0DMS8 2/20 0.32
YTHDC1 Q96MU7 1/20 0.32
ALDH1A1 P00352 1/20 0.30
THRB P10828 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1683802 0.78 ADORA2A (0.35) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL667204 0.77 ADORA2A (0.62) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL16949893 0.75 ADORA2A (0.37) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL3857168 0.75 ADORA1 (0.60) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL320849 0.75 ADORA2A (0.41) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL25325575 0.75 ADORA2A (0.33) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL15829723 0.75 ADORA2A (0.37) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL1868819 0.75 FDPS (0.44) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL16949944 0.75 ADORA2A (0.37) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL723948 0.75 ADORA2A (0.34) ADORA2AADORA1PI4KAPI4K2BPI4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102382871-A Improved method for producing 5'-flavor nucleotide SHANGHAI FUCHANG TECHNOLOGY CO LTD 2012-03-21 CN disclosed
CN-100575487-C A kind of method of production 5 '-flavour nucleotide UNIV FUDAN 2009-12-30 CN disclosed
CN-101063126-A Method for producing 5'-flavour development nucleic acid UNIV FUDAN (CN) 2007-10-31 CN disclosed
US-20070160981-A1 VIRAL PROTEASE NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2007-07-12 US disclosed
US-6589941-B1 Preventing or reducing formation of resistance in cytostatic treatment comprising combining BVDU, a salt thereof or BVDU in protected form or in prodrug form with at least one cytostatic agent in order to prevent or reduce the formation RESPROTECT GMBH (DE) 2003-07-08 US disclosed
EP-0806956-B1 USE OF 5'SUBSTITUTED NUCLEOSIDES TO PROVIDE RESISTANCE IN CYTOSTATIC TREATMENT RESPROTECT GMBH (DE) 2002-08-28 EP disclosed
EP-0806956-A1 USE OF 5'SUBSTITUTED NUCLEOSIDES TO PROVIDE RESISTANCE IN CYTOSTATIC TREATMENT AND MEDICAMENTS CONTAINING SAID NUCLEOSIDES FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) 1997-11-19 EP disclosed
WO-1996023506-A1 USE OF 5'SUBSTITUTED NUCLEOSIDES TO PROVIDE RESISTANCE IN CYTOSTATIC TREATMENT AND MEDICAMENTS CONTAINING SAID NUCLEOSIDES Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 1996-08-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070160981-A1 VIRAL PROTEASE XPNPEP1, PREP, XPNPEP2 ADORA2A 4805/4885ADORA1 4653/4885PI4KA 1774/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.