Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 12/20 | 0.56 |
| ▸ | NEK2 | P51955 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5813249 | 0.83 | SIRT1 (0.60) | SIRT1SIRT2NEK2AURKARHOA | |
| SCHEMBL13802509 | 0.79 | CXCL8 (0.57) | SIRT1SIRT2AURKA | |
| SCHEMBL21257499 | 0.75 | RAPGEF4 (0.51) | MAPK14 | |
| SCHEMBL28057053 | 0.75 | AURKA (0.64) | SIRT1SIRT2NEK2AURKARHOA | |
| SCHEMBL5777508 | 0.74 | ITGB3 (0.56) | SIRT1FFAR1 | |
| SCHEMBL2473717 | 0.73 | HTR3E (0.59) | — | |
| SCHEMBL30572312 | 0.73 | HTR3E (0.59) | — | |
| Hydrochloric Acid SCHEMBL31606746 | 0.71 | HTR3E (0.57) | — | |
| SCHEMBL5485489 | 0.70 | TYK2 (0.48) | — | |
| SCHEMBL1883307 | 0.70 | CXCL8 (0.54) | SIRT1SIRT2AURKAMAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856031-A1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' pha.r.ma s.p.a. (IT) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006063999-A1 | 2-ARYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' PHA.R.MA.S.P.A. (IT) | 2006-06-22 | — | — | WO | disclosed |