SCHEMBL5492629

SCHEMBL5492629

CC(N1CCOCC1)S(=O)(=O)[O-].CC(N1CCOCC1)S(=O)(=O)[O-].[Ca+2]

nearest known ligand 0.38

Known targets — ChEMBL curated mechanism

GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.38
CA7 P43166 1/20 0.38
CA14 Q9ULX7 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.36
PKM P14618 1/20 0.36
ALDH1A1 P00352 4/20 0.36
LMNA P02545 4/20 0.36
GAA P10253 1/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
TSHR P16473 2/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
KMT2A Q03164 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
POLB P06746 2/20 0.32
LIPE Q05469 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5497675 0.96 L3MBTL1 (0.38) CA12CA7CA14SMN1; SMN2PKM
Potassium Ion SCHEMBL8985015 0.96 CA12 (0.38) CA12CA7CA14SMN1; SMN2PKM
SCHEMBL30869985 0.96 L3MBTL1 (0.38) CA12CA7CA14SMN1; SMN2PKM
Water SCHEMBL28916298 0.94 L3MBTL1 (0.37) CA12CA7CA14SMN1; SMN2PKM
SCHEMBL3293117 0.80 LMNA (0.33) LMNAGAA
Potassium Ion SCHEMBL5383247 0.80 LMNA (0.33) LMNAGAA
SCHEMBL15572838 0.78 CA12 (0.41) CA12CA7CA14SMN1; SMN2PKM
SCHEMBL4694756 0.78 CA12 (0.41) CA12CA7CA14SMN1; SMN2PKM
SCHEMBL49152 0.77 CA12 (0.39) CA12CA7CA14SMN1; SMN2PKM
SCHEMBL29926166 0.77 CA12 (0.39) CA12CA7CA14SMN1; SMN2PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1111065-B1 Production of saccharide carboxylic acids ENSUIKO SUGAR REFINING (JP) 2007-09-26 EP disclosed
EP-0599646-B1 Production of saccharide carboxylic acids TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2002-09-18 EP disclosed
EP-1111065-A2 Production of saccharide carboxylic acids TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-06-27 EP disclosed
EP-0657176-B1 Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2000-09-20 EP disclosed
US-5840881-A ADDING A BRANCHED CYCLODEXTRIN-CARBOXYLIC ACID TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-11-24 US disclosed
US-5635611-A COMPLEXING DETRANYLGLUCURONIC ACID SALT WITH FERRIC HYDROXIDE SOL TO FORM A COMPLEX; RESISTANT TO ENZYMATIC DEGRADATION AND IMPROVED WATER SOLUBILITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-06-03 US disclosed
US-5635610-A FROM OXIDATION BY A MICROORGANISM BELONGING TO THE GENUS PSEUDOGLUCONOBACTER; RESISTANT TO ENZYMATIC DEGRADATION; IMPROVED WATER SOLUBILITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-06-03 US disclosed
US-5629411-A RESISTANT TO ENZYMATIC DEGRATION, IMPROVED WATER SOLUBILITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-05-13 US disclosed
US-5434061-A Pseudogluconobacter TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-07-18 US disclosed
EP-0657176-A2 Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-06-14 EP disclosed
EP-0634174-A1 Antianemic composition for veterinary use Takeda Chemical Industries, Ltd. (JP) 1995-01-18 EP disclosed
EP-0599646-A2 Production of saccharide carboxylic acids TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-06-01 EP disclosed