Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5492629 | 0.96 | CA12 (0.38) | CA12CA7CA14SMN1; SMN2PKM | |
| SCHEMBL30869985 | 0.96 | L3MBTL1 (0.38) | CA12CA7CA14SMN1; SMN2PKM | |
| SCHEMBL5497675 | 0.96 | L3MBTL1 (0.38) | CA12CA7CA14SMN1; SMN2PKM | |
| Water SCHEMBL28916298 | 0.94 | L3MBTL1 (0.37) | CA12CA7CA14SMN1; SMN2PKM | |
| Potassium Ion SCHEMBL5383247 | 0.84 | LMNA (0.33) | LMNAGAA | |
| SCHEMBL3293117 | 0.80 | LMNA (0.33) | LMNAGAA | |
| SCHEMBL4694756 | 0.78 | CA12 (0.41) | CA12CA7CA14SMN1; SMN2PKM | |
| SCHEMBL15572838 | 0.78 | CA12 (0.41) | CA12CA7CA14SMN1; SMN2PKM | |
| SCHEMBL49152 | 0.77 | CA12 (0.39) | CA12CA7CA14SMN1; SMN2PKM | |
| SCHEMBL29926166 | 0.77 | CA12 (0.39) | CA12CA7CA14SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397753-B1 | DETERMINATION OF GENETIC SEX IN RUMINANTS USING Y-CHROMOSOME-SPECIFIC POLYNUCLEOTIDES | ADVANCED RIVERINA HOLDINGS (AU) | 1996-06-12 | — | — | EP | disclosed |
| EP-0276287-B1 | SEX DETERMINATION IN RUMINANTS USING Y-CHROMOSOME SPECIFIC POLYNUCLEOTIDES | THE AUSTRALIAN NATIONAL UNIVERSITY (AU) | 1993-04-07 | — | — | EP | disclosed |
| EP-0397753-A4 | DETERMINATION OF GENETIC SEX IN RUMINANTS USING Y-CHROMOSOME-SPECIFIC POLYNUCLEOTIDES | — | 1991-06-19 | — | — | EP | disclosed |
| EP-0397753-A1 | DETERMINATION OF GENETIC SEX IN RUMINANTS USING Y-CHROMOSOME-SPECIFIC POLYNUCLEOTIDES. | ADVANCED RIVERINA HOLDINGS (AU) | 1990-11-22 | — | — | EP | disclosed |
| EP-0276287-A4 | SEX DETERMINATION IN RUMINANTS USING Y-CHROMOSOME SPECIFIC POLYNUCLEOTIDES. | UNIV AUSTRALIAN (AU) | 1989-09-19 | — | — | EP | disclosed |
| WO-1989007154-A1 | DETERMINATION OF GENETIC SEX IN RUMINANTS USING Y-CHROMOSOME-SPECIFIC POLYNUCLEOTIDES | ADVANCED RIVERINA HOLDINGS LIMITED (AU) | 1989-08-10 | — | — | WO | disclosed |
| EP-0276287-A1 | SEX DETERMINATION IN RUMINANTS USING Y-CHROMOSOME SPECIFIC POLYNUCLEOTIDES. | UNIV AUSTRALIAN (AU) | 1988-08-03 | — | — | EP | disclosed |
| WO-1988001300-A1 | SEX DETERMINATION IN RUMINANTS USING Y-CHROMOSOME SPECIFIC POLYNUCLEOTIDES | THE AUSTRALIAN NATIONAL UNIVERSITY (AU) | 1988-02-25 | — | — | WO | disclosed |