Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | GPR4 | P46093 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.37 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP10 | P09238 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498980 | 0.82 | GPR84 (0.46) | KCNH2GPR4TACR1 | |
| SCHEMBL5499307 | 0.81 | SIGMAR1 (0.49) | KCNH2GPR4SIGMAR1 | |
| SCHEMBL5500263 | 0.80 | KCNH2 (0.41) | KCNH2GPR4TACR1SIGMAR1REN | |
| SCHEMBL5502520 | 0.78 | KCNH2 (0.41) | KCNH2GPR4TACR1SIGMAR1REN | |
| SCHEMBL5495293 | 0.77 | P2RX7 (0.38) | KCNH2TACR1FFAR4 | |
| SCHEMBL5499921 | 0.74 | IDO1 (0.43) | SIGMAR1TRPV1 | |
| SCHEMBL7428659 | 0.73 | TACR1 (0.42) | EPHX1KCNH2GPR4TACR1 | |
| SCHEMBL5500050 | 0.73 | KCNH2 (0.43) | KCNH2GPR4TACR1REN | |
| SCHEMBL5502120 | 0.73 | SLC6A2 (0.38) | KCNH2TACR1FFAR4 | |
| SCHEMBL5502309 | 0.73 | KCNH2 (0.38) | KCNH2GPR4TACR1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765779-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005121092-A1 | NEW SUBSTITUTED PIPERIDINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |