SCHEMBL5496877

SCHEMBL5496877

CCC(OC(C)=O)C(=O)OC[C@@H]1C=C[C@H](n2cc(F)c(N)nc2=O)O1

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALB P02768 1/20 0.38
POLG P54098 1/20 0.35
EP300 Q09472 1/20 0.32
DUT P33316 1/20 0.31
DCK P27707 2/20 0.31
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1738785 0.87 ALB (0.43) ALBPOLGEP300DUTDCK
SCHEMBL5496874 0.82 ALB (0.38) ALBPOLGEP300DCKLMNA
SCHEMBL12149532 0.79 ALB (0.44) ALBPOLGEP300DUTDCK
SCHEMBL13594946 0.77 ALB (0.46) ALBPOLGEP300DUTDCK
SCHEMBL5494937 0.75 BCHE (0.47)
Dexelvucitabine SCHEMBL599014 0.75 ALB (0.55) ALBPOLGDCKLMNA
Elvucitabine SCHEMBL3298257 0.75 ALB (0.55) ALBPOLGDCKLMNA
Elvucitabine SCHEMBL1649928 0.75 ALB (0.55) ALBPOLGDCKLMNA
SCHEMBL13770316 0.74 ALB (0.47) ALBPOLGDUTDCKLMNA
SCHEMBL4285526 0.73 LMNA (0.39) ALBDUTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1654270-B1 PROCESS FOR PREPARING 2',3'-DIDEHYDRO-2',3'-DIDEOXYNUCLEOSIDES AND 2',3'-DIDEOXYNUCLEOSIDES ARCHIMICA SRL (IT) 2007-12-26 EP disclosed
US-20060199959-A1 Process for preparing 2',3'-didehydro-2'3'-dideoxynucleosides and 2',3'-dideoxynucleosides ARCHIMICA S.R.L. (IT) 2006-09-07 US disclosed
EP-1654270-A1 PROCESS FOR PREPARING 2',3'-DIDEHYDRO-2',3'-DIDEOXYNUCLEOSIDES AND 2',3'-DIDEOXYNUCLEOSIDES Clariant Life Science Molecules (Italia) S.p.A. (IT) 2006-05-10 EP disclosed
WO-2005012325-A1 PROCESS FOR PREPARING 2',3'-DIDEHYDRO-2',3'-DIDEOXYNUCLEOSIDES AND 2',3'-DIDEOXYNUCLEOSIDES CLARIANT LIFE SCIENCE MOLECULES (ITALIA) S.P.A. (IT) 2005-02-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060199959-A1 Process for preparing 2',3'-didehydro-2'3'-dideoxynucleosides and 2',3'-dideoxynucleosides DOHH, UMPS, DCPS ALB 3795/4885POLG 164/4885EP300 3657/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.