Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.67 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MGAM | O43451 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SI | P14410 | 1/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5114943 | 0.80 | AR (1.00) | ARLMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL5112521 | 0.76 | AR (0.70) | ARLMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL5112528 | 0.76 | AR (0.70) | ARLMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL7689804 | 0.76 | RAB9A (0.63) | LMNASMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL5503497 | 0.70 | LMNA (0.85) | ARLMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL18155143 | 0.69 | AR (1.00) | ARLMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL22640100 | 0.68 | KDM4E (0.77) | ARLMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL374823 | 0.68 | ALDH1A1 (0.59) | ALDH1A1TDP1MGAMGAASI | |
| SCHEMBL12195163 | 0.68 | ALDH1A1 (0.71) | MAPTSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL11687629 | 0.68 | CYP1A2 (0.65) | ARLMNAMAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |