Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6250233 | 0.82 | FAAH (0.45) | CTSKRAB9AHPGDLMNASMN1; SMN2 | |
| SCHEMBL1461981 | 0.81 | ATM (0.60) | CTSKRAB9AHPGDLMNASMN1; SMN2 | |
| SCHEMBL11491274 | 0.81 | ATM (0.60) | CTSKRAB9AHPGDLMNASMN1; SMN2 | |
| SCHEMBL6250228 | 0.80 | TGM2 (0.47) | CTSKRAB9AHPGDLMNASMN1; SMN2 | |
| SCHEMBL27695165 | 0.77 | ITGB3 (0.41) | CTSKRAB9AHPGDLMNAFAAH | |
| SCHEMBL27993584 | 0.77 | RAB9A (0.39) | CTSKRAB9AHPGDLMNASMN1; SMN2 | |
| SCHEMBL5503388 | 0.76 | CTSK (0.48) | CTSKRAB9ALMNASMN1; SMN2NPC1 | |
| SCHEMBL4597773 | 0.76 | EPHX2 (0.48) | CTSKRAB9AHPGDLMNASMN1; SMN2 | |
| SCHEMBL5088823 | 0.76 | FOLH1 (0.46) | RAB9AHPGDLMNASMN1; SMN2NPC1 | |
| SCHEMBL1553456 | 0.76 | FOLH1 (0.51) | CTSKRAB9AHPGDLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791837-A1 | SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER | F. Hoffmann-Roche AG (CH) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006029862-A1 | SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |