Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 5/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502402 | 0.78 | HTR7 (0.53) | SNCAGPR84MEN1KMT2A | |
| SCHEMBL5899817 | 0.78 | MEN1 (0.59) | SNCASLC6A4MEN1KMT2ADRD2 | |
| SCHEMBL29005985 | 0.77 | SLC6A4 (0.62) | SLC6A4GPR84DRD2DRD4DRD3 | |
| SCHEMBL3601687 | 0.74 | IMPDH2 (0.51) | SLC6A4 | |
| SCHEMBL18011073 | 0.73 | SLC6A4 (0.56) | SLC6A4DRD2DRD4DRD3 | |
| SCHEMBL3969159 | 0.73 | MEN1 (0.70) | GPR84MEN1KMT2A | |
| SCHEMBL13226846 | 0.71 | SLC6A4 (0.63) | SLC6A4MEN1KMT2ADRD2DRD4 | |
| SCHEMBL30665978 | 0.71 | GABRP (0.60) | SLC6A4 | |
| SCHEMBL2535253 | 0.71 | GABRP (0.60) | SLC6A4 | |
| SCHEMBL2648422 | 0.71 | ALDH1A1 (0.66) | SLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751103-A1 | 4-(5-(AMINOMETHYL)-INDOLE-1-YLMETHYL)-BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS OPIOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY | ELI LILLY AND COMPANY (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005090303-A1 | 4- (5- (AMINOMETHYL) -INDOLE-1-YLMETHYL) -BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS OPIOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY | ELI LILLY AND COMPANY (US) | 2005-09-29 | — | — | WO | disclosed |