Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | HTR1B | P28222 | 3/20 | 0.53 |
| ▸ | HTR6 | P50406 | 3/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR5A | P47898 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | HTR1E | P28566 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30844121 | 0.79 | NQO2 (0.54) | HTR7HTR1AHTR1BHTR6HTR2C | |
| SCHEMBL5500496 | 0.78 | SNCA (0.48) | MEN1KMT2ASNCAGPR84 | |
| SCHEMBL5501366 | 0.76 | HTR1A (0.45) | HTR7HTR1AHTR1BHTR6HTR2C | |
| SCHEMBL5496225 | 0.76 | CYP1A2 (0.45) | HTR7HTR1AHTR1BHTR6HTR2C | |
| SCHEMBL5499448 | 0.76 | CYP1A2 (0.45) | HTR7HTR1AHTR1BHTR6HTR2C | |
| SCHEMBL5500442 | 0.76 | HTR1D (0.47) | HTR7HTR1AHTR1BHTR6HTR2C | |
| SCHEMBL2648422 | 0.75 | ALDH1A1 (0.66) | HTR7HTR1AHTR1BHTR6HTR2C | |
| SCHEMBL5498300 | 0.75 | MPO (0.53) | HTR7HTR1AHTR1BHTR6HTR2C | |
| SCHEMBL5495196 | 0.73 | SNCA (0.58) | HTR7HTR1AHTR1BHTR6HTR2C | |
| SCHEMBL5498985 | 0.73 | HTR2A (0.60) | KMT2ASNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751103-A1 | 4-(5-(AMINOMETHYL)-INDOLE-1-YLMETHYL)-BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS OPIOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY | ELI LILLY AND COMPANY (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005090303-A1 | 4- (5- (AMINOMETHYL) -INDOLE-1-YLMETHYL) -BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS OPIOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY | ELI LILLY AND COMPANY (US) | 2005-09-29 | — | — | WO | disclosed |