SCHEMBL5500899

SCHEMBL5500899

CN(CCNc1ccc(OC(F)(F)F)cc1)C(=O)C(SCc1ccccc1)C(N)=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 4/20 0.52
CTSS P25774 3/20 0.41
CTSL P07711 1/20 0.41
CTSK P43235 1/20 0.41
FPR2 P25090 1/20 0.41
ACHE P22303 1/20 0.40
POLB P06746 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC10 Q969S8 1/20 0.38
HDAC11 Q96DB2 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
HDAC9 Q9UKV0 1/20 0.38
HDAC5 Q9UQL6 1/20 0.38
MAPT P10636 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5398975 0.81 FPR2 (0.43) EPHX1CTSSFPR2ACHEPOLB
SCHEMBL6685718 0.73 TDP1 (0.48) EPHX1CTSSCTSLCTSKPOLB
SCHEMBL5500897 0.71 EPHX1 (0.42) EPHX1CTSSCTSLCTSKFPR2
SCHEMBL6688714 0.71 POLB (0.47) EPHX1POLBL3MBTL1HDAC3HDAC4
SCHEMBL9422891 0.71 ACHE (0.61) ACHEPOLBMAPTPLA2G1BSMN1; SMN2
SCHEMBL9422846 0.71 FPR2 (0.46) EPHX1CTSSFPR2ACHEPOLB
SCHEMBL6688710 0.69 POLB (0.43) EPHX1POLBL3MBTL1HDAC3HDAC4
SCHEMBL6688737 0.69 CTSS (0.47) CTSSCTSLCTSKL3MBTL1SCN9A
SCHEMBL6688734 0.69 CTSS (0.57) CTSSCTSLCTSK
SCHEMBL3024781 0.68 CTSS (0.67) CTSSCTSLCTSKACE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1658267-A4 INHIBITORS OF CATHEPSIN S IRM LLC (BM) 2007-08-01 EP disclosed
EP-1658267-A2 INHIBITORS OF CATHEPSIN S IRM LLC (BM) 2006-05-24 EP disclosed
WO-2005034848-A2 INHIBITORS OF CATHEPSIN S IRM LLC (BM) 2005-04-21 WO disclosed